PMID- 21318185
OWN - NLM
STAT- MEDLINE
DCOM- 20110524
LR  - 20211020
IS  - 1687-5303 (Electronic)
IS  - 1687-5214 (Print)
IS  - 1687-5214 (Linking)
VI  - 2010
DP  - 2010
TI  - Deletion of the Men1 gene prevents streptozotocin-induced hyperglycemia in mice.
PG  - 876701
LID - 10.1155/2010/876701 [doi]
LID - 876701
AB  - Diabetes ultimately results from an inadequate number of functional beta cells in 
      the islets of Langerhans. Enhancing proliferation of functional endogenous beta 
      cells to treat diabetes remains underexplored. Here, we report that excision of 
      the Men1 gene, whose loss-of-function mutation leads to inherited multiple 
      endocrine neoplasia type 1 (MEN1), rendered resistant to streptozotocin-induced 
      hyperglycemia in a tamoxifen-inducible and temporally controlled Men1 excision 
      mouse model as well as in a tissue-specific Men1 excision mouse model. Men1 
      excision prevented mice from streptozotocin-induced hyperglycemia mainly through 
      increasing the number of functional beta cells. BrdU incorporation by beta cells, 
      islet size, and circulating insulin levels were significantly increased in 
      Men1-excised mice. Membrane localization of glucose transporter 2 was largely 
      preserved in Men1-excised beta cells, but not in Men1-expressing beta cells. Our 
      findings suggest that repression of menin, a protein encoded by the Men1 gene, 
      might be a valuable means to maintain or increase the number of functional 
      endogenous beta cells to prevent or ameliorate diabetes.
FAU - Yang, Yuqing
AU  - Yang Y
AD  - Abramson Family Cancer Research Institute, Department of Cancer Biology, Abramson 
      Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA.
FAU - Wang, Haoren
AU  - Wang H
FAU - Hua, Xianxin
AU  - Hua X
LA  - eng
GR  - R01 DK085121/DK/NIDDK NIH HHS/United States
GR  - R01 DK097555/DK/NIDDK NIH HHS/United States
GR  - R01-DK085121/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110117
PL  - United States
TA  - Exp Diabetes Res
JT  - Experimental diabetes research
JID - 101274844
RN  - 0 (Glucose Transporter Type 2)
RN  - 0 (Men1 protein, mouse)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Slc2a2 protein, mouse)
RN  - 5W494URQ81 (Streptozocin)
SB  - IM
MH  - Animals
MH  - Cell Proliferation
MH  - Diabetes Mellitus, Experimental/*prevention & control
MH  - Glucose Transporter Type 2/analysis
MH  - Hyperglycemia/*prevention & control
MH  - Insulin-Secreting Cells/physiology
MH  - Male
MH  - Mice
MH  - Proto-Oncogene Proteins/genetics/*physiology
MH  - Streptozocin
PMC - PMC3034935
EDAT- 2011/02/15 06:00
MHDA- 2011/05/25 06:00
PMCR- 2011/01/17
CRDT- 2011/02/15 06:00
PHST- 2010/09/16 00:00 [received]
PHST- 2010/11/09 00:00 [revised]
PHST- 2010/12/03 00:00 [accepted]
PHST- 2011/02/15 06:00 [entrez]
PHST- 2011/02/15 06:00 [pubmed]
PHST- 2011/05/25 06:00 [medline]
PHST- 2011/01/17 00:00 [pmc-release]
AID - 10.1155/2010/876701 [doi]
PST - ppublish
SO  - Exp Diabetes Res. 2010;2010:876701. doi: 10.1155/2010/876701. Epub 2011 Jan 17.