PMID- 21318566
OWN - NLM
STAT- MEDLINE
DCOM- 20110901
LR  - 20211020
IS  - 1432-2072 (Electronic)
IS  - 0033-3158 (Linking)
VI  - 215
IP  - 3
DP  - 2011 Jun
TI  - MDMA and methamphetamine: some paradoxical negative and positive mood changes in 
      an acute dose laboratory study.
PG  - 527-36
LID - 10.1007/s00213-011-2184-9 [doi]
AB  - RATIONALE: This study investigated the acute mood effects of oral MDMA, 
      methamphetamine, and placebo in a double-blind laboratory study. METHODS: 
      Fifty-two healthy participants comprised abstinent recreational users of 
      stimulant drugs, 27 female and 25 male, mean age 24.8 years. Three test sessions 
      involved acute 100 mg oral 3.4-methylendioxymethamphetamine (MDMA), 0.42 mg/kg 
      oral methamphetamine, and matching placebo. Drug administration was 
      counterbalanced, testing was double-blind, and medical supervision was present 
      throughout. Car-driving performance on a laboratory simulator was assessed after 
      3 and 24 h, with the findings being presented elsewhere. Positive and negative 
      moods (PANAS self-ratings) were completed before drug administration, 3, 4.5, and 
      24 h later. Blood samples were taken to monitor drug plasma levels. RESULTS: 
      Following MDMA, there were no significant increases in positive moods, whereas 
      negative moods were significantly higher than under placebo. Methamphetamine led 
      to significant increases in both positive and negative moods. The MDMA findings 
      contrast with the elated moods, typically noted by dance clubbers on Ecstasy. 
      However, they are consistent with some previous laboratory findings, since a wide 
      array of positive and negative mood changes have been demonstrated. One possible 
      explanatory factor was the neutral environmental situation, particularly if a 
      primary action of MDMA is to intensify ongoing psychological states. Other 
      explanatory factors, such as dosage, gender, post-drug timing, neurohormonal 
      aspects, and social factors, are also discussed. CONCLUSIONS: In the laboratory, 
      acute methamphetamine led to significantly higher positive moods. However, 
      against expectations, MDMA did not generate a significant increase in positive 
      moods.
FAU - Parrott, Andrew C
AU  - Parrott AC
AD  - Brain Sciences Institute, Swinburne University, Melbourne, VIC, Australia. 
      a.c.parrott@swansea.ac.uk
FAU - Gibbs, Amy
AU  - Gibbs A
FAU - Scholey, Andrew B
AU  - Scholey AB
FAU - King, Rebecca
AU  - King R
FAU - Owens, Katherine
AU  - Owens K
FAU - Swann, Phil
AU  - Swann P
FAU - Ogden, Ed
AU  - Ogden E
FAU - Stough, Con
AU  - Stough C
LA  - eng
GR  - DA-14910/DA/NIDA NIH HHS/United States
PT  - Comparative Study
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110212
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Central Nervous System Stimulants)
RN  - 44RAL3456C (Methamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Administration, Oral
MH  - Adult
MH  - Affect/*drug effects
MH  - Automobile Driving
MH  - Central Nervous System Stimulants/administration & dosage/*pharmacology
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Male
MH  - Methamphetamine/administration & dosage/*pharmacology
MH  - N-Methyl-3,4-methylenedioxyamphetamine/administration & dosage/*pharmacology
MH  - Time Factors
MH  - Young Adult
EDAT- 2011/02/15 06:00
MHDA- 2011/09/02 06:00
CRDT- 2011/02/15 06:00
PHST- 2010/06/25 00:00 [received]
PHST- 2011/01/17 00:00 [accepted]
PHST- 2011/02/15 06:00 [entrez]
PHST- 2011/02/15 06:00 [pubmed]
PHST- 2011/09/02 06:00 [medline]
AID - 10.1007/s00213-011-2184-9 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2011 Jun;215(3):527-36. doi: 
      10.1007/s00213-011-2184-9. Epub 2011 Feb 12.