PMID- 21318814
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20110214
IS  - 1543-1894 (Print)
IS  - 1543-1894 (Linking)
VI  - 50
DP  - 2001
TI  - Fluorescence in situ hybridization : application in cancer research and clinical 
      diagnostics.
PG  - 35-50
LID - 10.1385/1-59259-084-5:35 [doi]
AB  - An opportunity to look inside of the individual cell for the direct visualization 
      in situ of "what happened?" is the most wonderful feature offered by fluorescence 
      in situ hybridization (FISH). DNA in situ hybridization is a technique that 
      allows the visualization of defined sequences of nucleic acids within the 
      individual cells. The method is based on the site specific annealing 
      (hybridization) of single-stranded labeled DNA fragments (probes) to denatured, 
      homologous sequences (targets) on cytological preparations, like metaphase 
      chromosomes, interphase nuclei, or naked chromatin fibers. Visualization of 
      hybridization sites becomes possible after detection steps by using a wide 
      spectrum of the fluorescent dyes available.
FAU - Pack, S D
AU  - Pack SD
AD  - Laboratory of Pathology, National Cancer Institute, NIH, Bethesda, MD.
FAU - Zhuang, Z
AU  - Zhuang Z
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Methods Mol Med
JT  - Methods in molecular medicine
JID - 101123138
EDAT- 2001/01/01 00:00
MHDA- 2001/01/01 00:01
CRDT- 2011/02/15 06:00
PHST- 2011/02/15 06:00 [entrez]
PHST- 2001/01/01 00:00 [pubmed]
PHST- 2001/01/01 00:01 [medline]
AID - 10.1385/1-59259-084-5:35 [doi]
PST - ppublish
SO  - Methods Mol Med. 2001;50:35-50. doi: 10.1385/1-59259-084-5:35.