PMID- 21318988
OWN - NLM
STAT- MEDLINE
DCOM- 20110720
LR  - 20110214
IS  - 2185-2243 (Electronic)
IS  - 0385-0005 (Linking)
VI  - 34
IP  - 1
DP  - 2009 Apr 20
TI  - Histopathological study of specimens obtained by left ventricular biopsy during 
      ventriculoplasty for idiopathic dilated cardiomyopathy.
PG  - 1-7
AB  - OBJECTIVE: Pathological changes in the myocardium in idiopathic dilated 
      cardiomyopathy (DCM) are usually studied using endomyocardial biopsy specimens, 
      but the relationship between pathological changes in the myocardium and clinical 
      findings is unclear. The goal of the study was to examine correlations between 
      clinical findings and histopathological findings in specimens of the left 
      ventricular myocardium collected during left ventriculoplasty in DCM patients. 
      METHODS: The subjects were 20 DCM patients (17 males and 3 females; mean age: 59 
      +/- 14 years old) who underwent left ventriculoplasty, including 16 cases of 
      overlapping ventriculoplasty (OLVP) and 4 of papillary muscle approximation (PMA) 
      with left ventricular incision. Preoperative age, sex, The New York Heart 
      Association (NYHA) classification, the brain natriuretic peptide (BNP) level, 
      cardiothoracic ratio (CTR), echocardiographic data, history of diabetes mellitus, 
      drug history of spironolactone, ACE inhibitor, ARB, and beta-blocker were used as 
      clinical findings. Histopathological scores were determined for each patient and 
      semi-quantitative data for hypertrophy, attenuation, vacuolation and fibrosis 
      were obtained. RESULTS: A significant correlation was found between age and 
      interstitial fibrosis. A significant inverse correlation was found between left 
      ventricular diastolic diameter (LVDd) in echocardiographic data and interstitial 
      fibrosis. There were no other significant relation between histopathological 
      scores and clinical findings. CONCLUSION: From this study, we found that 
      interstitial fibrous increased with aging and more dilated LVDd had less 
      interstitial fibrosis. It is concluded that the kinetics of myocardial fibrosis 
      with remodeling might be variable and histopathological findings does not reflect 
      the clinical and hemodynamic changes in DCM patients. Further morphological data 
      are needed to verify this result.
FAU - Shimura, Shinichiro
AU  - Shimura S
AD  - Department of Cardiovascular Surgery, Tokai University School of Medicine, 143 
      Shimokasuya, Isehara, Kanagawa 259-1193, Japan. shimura@is.icc.u-tokai.ac.jp
FAU - Matsui, Yoshiro
AU  - Matsui Y
FAU - Yutani, Chikao
AU  - Yutani C
FAU - Suto, Yukio
AU  - Suto Y
FAU - Akashi, Okihiko
AU  - Akashi O
FAU - Matsui, Kinya
AU  - Matsui K
FAU - Shingu, Yasushige
AU  - Shingu Y
FAU - Sakakibara, Mamoru
AU  - Sakakibara M
FAU - Yamaguchi, Masaomi
AU  - Yamaguchi M
FAU - Haruki, Yasuo
AU  - Haruki Y
FAU - Takigami, Kou
AU  - Takigami K
FAU - Minase, Takashi
AU  - Minase T
FAU - Ueda, Toshihiko
AU  - Ueda T
LA  - eng
PT  - Journal Article
DEP - 20090420
PL  - Japan
TA  - Tokai J Exp Clin Med
JT  - The Tokai journal of experimental and clinical medicine
JID - 7704186
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biopsy
MH  - Cardiomyopathy, Dilated/*pathology/*surgery
MH  - Echocardiography
MH  - Female
MH  - Fibrosis
MH  - Heart Ventricles/*pathology/*surgery
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardium/pathology
MH  - Natriuretic Peptide, Brain/metabolism
EDAT- 2009/01/01 00:00
MHDA- 2011/07/21 06:00
CRDT- 2011/02/15 06:00
PHST- 2008/10/07 00:00 [received]
PHST- 2008/11/17 00:00 [accepted]
PHST- 2011/02/15 06:00 [entrez]
PHST- 2009/01/01 00:00 [pubmed]
PHST- 2011/07/21 06:00 [medline]
PST - epublish
SO  - Tokai J Exp Clin Med. 2009 Apr 20;34(1):1-7.