PMID- 21319854
OWN - NLM
STAT- MEDLINE
DCOM- 20110630
LR  - 20190606
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 59
IP  - 5
DP  - 2011 Mar 9
TI  - Apple polyphenols extend the mean lifespan of Drosophila melanogaster.
PG  - 2097-106
LID - 10.1021/jf1046267 [doi]
AB  - Apple polyphenols (AP) are an excellent source of dietary antioxidants. The 
      present study investigated the effect of AP on the lifespan of fruit flies and 
      their interaction with gene expressions of superoxide dismutase (SOD), catalase 
      (CAT), methuselah (MTH), Rpn11, and cytochrome c oxidase (CcO) subunits III and 
      VIb. Results showed the mean lifespan was significantly extended by 10% in fruit 
      flies fed the AP diet. This was accompanied by up-regulation of genes SOD1, SOD2, 
      and CAT and down-regulation of MTH in the aged fruit flies. Paraquat and H(2)O(2) 
      challenge tests demonstrated that AP prolonged the survival time only for Oregon 
      R wild type flies but not for SOD(n108) or Cat(n1) mutants, in which either SOD 
      or CAT was knocked out. Chronic paraquat exposure could shorten the maximum 
      lifespan from 68 to 31 days and reduce the climbing ability by 60%, whereas AP 
      could partially reverse the paraquat-induced mortality and decline in climbing 
      ability. AP could up-regulate Rpn11 at day 30, whereas it appeared to have no 
      significant effect on gene expression of ubiquitinated protein, CcO subunits III 
      and VIb. These AP-induced changes were unlikely associated with caloric 
      restriction as the gustatory assay found no difference in average body weight and 
      stomach redness index between the control and AP fruit flies. It was therefore 
      concluded that the antiaging activity of AP was, at least in part, mediated by 
      its interaction with genes SOD, CAT, MTH, and Rpn11.
FAU - Peng, Cheng
AU  - Peng C
AD  - Food and Nutritional Sciences Programme, School of Life Sciences, The Chinese 
      University of Hong Kong , Hong Kong, China.
FAU - Chan, Ho Yin Edwin
AU  - Chan HY
FAU - Huang, Yu
AU  - Huang Y
FAU - Yu, Hongjian
AU  - Yu H
FAU - Chen, Zhen-Yu
AU  - Chen ZY
LA  - eng
PT  - Journal Article
DEP - 20110214
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Drosophila Proteins)
RN  - 0 (Flavonoids)
RN  - 0 (Phenols)
RN  - 0 (Polyphenols)
RN  - 0 (Receptors, G-Protein-Coupled)
RN  - 0 (mth protein, Drosophila)
RN  - BBX060AN9V (Hydrogen Peroxide)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 1.9.3.1 (Electron Transport Complex IV)
RN  - PLG39H7695 (Paraquat)
SB  - IM
MH  - Animals
MH  - Catalase/genetics
MH  - Diet
MH  - Down-Regulation/drug effects
MH  - Drosophila Proteins/genetics
MH  - Drosophila melanogaster/*drug effects/genetics/*physiology
MH  - Electron Transport Complex IV/genetics
MH  - Flavonoids/*pharmacology
MH  - Fruit/*chemistry
MH  - Hydrogen Peroxide/pharmacology
MH  - Longevity/drug effects
MH  - Malus/*chemistry
MH  - Paraquat/pharmacology
MH  - Phenols/*pharmacology
MH  - Polyphenols
MH  - Receptors, G-Protein-Coupled/genetics
MH  - Superoxide Dismutase/genetics
MH  - Up-Regulation/drug effects
EDAT- 2011/02/16 06:00
MHDA- 2011/07/01 06:00
CRDT- 2011/02/16 06:00
PHST- 2011/02/16 06:00 [entrez]
PHST- 2011/02/16 06:00 [pubmed]
PHST- 2011/07/01 06:00 [medline]
AID - 10.1021/jf1046267 [doi]
PST - ppublish
SO  - J Agric Food Chem. 2011 Mar 9;59(5):2097-106. doi: 10.1021/jf1046267. Epub 2011 
      Feb 14.