PMID- 21319977
OWN - NLM
STAT- MEDLINE
DCOM- 20110524
LR  - 20221207
IS  - 1557-8976 (Electronic)
IS  - 0882-8245 (Linking)
VI  - 24
IP  - 1
DP  - 2011 Feb
TI  - Chinese human immunodeficiency virus-1 patients with different routes of 
      transmission exhibit altered expression levels of blood dendritic cell 
      subpopulations.
PG  - 35-43
LID - 10.1089/vim.2010.0038 [doi]
AB  - Dendritic cells (DCs) play a pivotal role in the pathogenesis of human 
      immunodeficiency virus-1 (HIV-1). Reduced numbers of blood DCs have been observed 
      in individuals with chronic HIV-1 infection. In the present study, we analyzed 
      the expression levels of monocytes, myeloid dendritic cell (mDC) precursors, 
      mDCs, and plasmacytoid dendritic cells (pDCs), in HIV-1-infected patients in 
      China who were infected via different routes of transmission, including 
      heterosexual and homosexual sexual contact, and blood transmission through 
      importation of blood or blood products, to further elucidate their role in HIV. 
      Compared with HIV-negative individuals (n = 40), relative levels of 
      CD11c+CD14(-)mDCs, CD11c++CD123(low) mDCs, and CD11c(-)CD123+ pDCs in total 
      peripheral blood mononuclear cells (PBMCs) were significantly lower in all HIV 
      patients (n = 93), and in those with blood transmission (n = 26) and heterosexual 
      transmission (n = 43), while relative levels of CD11c+CD14(-)mDCs were 
      significantly lower in HIV patients infected via homosexual transmission 
      (n = 24). The results of correlation analysis demonstrated a significant negative 
      correlation between CD4+ T-cell counts and the relative levels of 
      CD11c++CD123(low) mDCs in HIV-I patients infected via blood transmission. There 
      was no significant correlation between CD4+ T-cell counts and the expression 
      level of other DC subpopulations in PBMCs from HIV patients. The results of this 
      study suggest that HIV-1 patients with different routes of transmission exhibit 
      altered expression levels of blood DC subpopulations, which contributes to 
      dysregulated immune responses and pathogenesis of HIV-1.
FAU - Zhao, Jun-Li
AU  - Zhao JL
AD  - Immunology and Reproductive Biology Laboratory of Medical School and State Key 
      Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China.
FAU - Hao, Sha
AU  - Hao S
FAU - Feng, Min-Min
AU  - Feng MM
FAU - Li, Peng-Fei
AU  - Li PF
FAU - Gong, Wei
AU  - Gong W
FAU - Xu, Xiao-Qin
AU  - Xu XQ
FAU - Huan, Xi-Ping
AU  - Huan XP
FAU - Fu, Geng-Feng
AU  - Fu GF
FAU - Hou, Ya-Yi
AU  - Hou YY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Viral Immunol
JT  - Viral immunology
JID - 8801552
RN  - 0 (CD11c Antigen)
RN  - 0 (IL3RA protein, human)
RN  - 0 (Interleukin-3 Receptor alpha Subunit)
RN  - 0 (Lipopolysaccharide Receptors)
SB  - IM
MH  - Adult
MH  - Asian People
MH  - Blood/immunology
MH  - CD11c Antigen/analysis
MH  - CD4 Lymphocyte Count
MH  - China
MH  - Dendritic Cells/chemistry/*immunology
MH  - Female
MH  - HIV Infections/*immunology
MH  - HIV-1/*immunology
MH  - Humans
MH  - Interleukin-3 Receptor alpha Subunit/analysis
MH  - Lipopolysaccharide Receptors/analysis
MH  - Male
MH  - Middle Aged
EDAT- 2011/02/16 06:00
MHDA- 2011/05/25 06:00
CRDT- 2011/02/16 06:00
PHST- 2011/02/16 06:00 [entrez]
PHST- 2011/02/16 06:00 [pubmed]
PHST- 2011/05/25 06:00 [medline]
AID - 10.1089/vim.2010.0038 [doi]
PST - ppublish
SO  - Viral Immunol. 2011 Feb;24(1):35-43. doi: 10.1089/vim.2010.0038.