PMID- 21320133
OWN - NLM
STAT- MEDLINE
DCOM- 20110815
LR  - 20220321
IS  - 1398-9995 (Electronic)
IS  - 0105-4538 (Linking)
VI  - 66
IP  - 6
DP  - 2011 Jun
TI  - 100 years of hyposensitization: history of allergen-specific immunotherapy 
      (ASIT).
PG  - 713-24
LID - 10.1111/j.1398-9995.2010.02541.x [doi]
AB  - Hundred years ago, Leonhard Noon and John Freeman published their pioneering 
      works on allergen-specific immunotherapy (ASIT) using grass pollen extracts. To 
      honor their contribution to the development of ASIT as the only causal treatment 
      of IgE-mediated allergies, we review the history of ASIT that started with the 
      anecdotal descriptions of ASIT performed by the ancient king Mithridates (132-63 
      B.C.) and Jenner's development of a cowpox vaccine. Following Noon's and 
      Freeman's first controlled human trials, ASIT was performed by a large number of 
      modalities and with a myriad of pharmacologic preparations. These developments 
      range from early aqueous pollen extracts and whole bee extracts to chemically 
      modified allergens (allergoids) and various recombinant allergens. In addition to 
      allergen-specific immunotherapy, non-specific immune response modifiers have been 
      used in the past or are in the developmental stage. Also, currently many 
      innovative experimental approaches of ASIT are studied in animal models and human 
      in vitro systems and will hopefully further broaden the range of allergies that 
      can be treated by ASIT, with enhanced efficacy and further reduced side-effects.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Ring, Johannes
AU  - Ring J
AD  - Department of Dermatology and Allergy Biederstein, Technische Universitat 
      Munchen, Munich, Germany. Johannes.ring@lrz.tu-muenchen.de
FAU - Gutermuth, J
AU  - Gutermuth J
LA  - eng
PT  - Historical Article
PT  - Journal Article
DEP - 20110215
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Allergens)
SB  - IM
CIN - Allergy. 2012 Jan;67(1):138-9; author reply 139-40. PMID: 21899559
MH  - Allergens/*administration & dosage/therapeutic use
MH  - Animals
MH  - Desensitization, Immunologic/*history/methods/trends
MH  - History, 19th Century
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Hypersensitivity, Immediate/*immunology/*therapy
EDAT- 2011/02/16 06:00
MHDA- 2011/08/16 06:00
CRDT- 2011/02/16 06:00
PHST- 2011/02/16 06:00 [entrez]
PHST- 2011/02/16 06:00 [pubmed]
PHST- 2011/08/16 06:00 [medline]
AID - 10.1111/j.1398-9995.2010.02541.x [doi]
PST - ppublish
SO  - Allergy. 2011 Jun;66(6):713-24. doi: 10.1111/j.1398-9995.2010.02541.x. Epub 2011 
      Feb 15.