PMID- 21320562
OWN - NLM
STAT- MEDLINE
DCOM- 20110817
LR  - 20151119
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 72
IP  - 5
DP  - 2011 May
TI  - Donor human leukocyte antigen specific antibodies predict development and define 
      prognosis in transplant glomerulopathy.
PG  - 386-91
LID - 10.1016/j.humimm.2011.02.002 [doi]
AB  - The pathogenesis of transplant glomerulopathy (TG) remains unclear, with evidence 
      of human leukocyte antigen (HLA) antibodies as important contributors to the 
      disease. We studied the risk factors and the associations of HLA antibodies in 
      the development of TG. Sixty-one cases with morphologic features of TG were 
      identified and compared with contemporaneous matched patients (without TG) from a 
      17-year period, all undergoing renal biopsy in a single center. Univariate risk 
      factors for TG were previous glomerulitis [odds ratio (OR) 3.3, 95% confidence 
      interval (95% CI) [1.2-9.4], p = 0.025), delayed graft function (OR 2.3 
      [1.0-5.1], p = 0.042), HLA class I presensitization defined by Luminex 
      solid-phase immunoassays (OR 5.0 [2.3-11.0]. p < 0.001), and de novo 
      posttransplant development of donor HLA specific antibody (DSA) (OR 4.7 
      [1.7-13.2], p = 0.002). Only DSA remained significantly associated with TG after 
      adjustment (OR 3.8 [1.1-12.9], p = 0.032). DSA was detected in >50% of TG 
      patients, suggesting HLA antibodies play a critical role in TG pathogenesis. TG 
      patients with DSA had increased risk of graft loss (median graft survival 4.4-5.2 
      years), whereas patients with morphologic features of TG without DSA had similar 
      graft survival compared with the non-TG group (median graft survival 15 years). 
      Thus, DSA is a useful predictor for graft failure in TG patients.
CI  - Crown Copyright (c) 2011. Published by Elsevier Inc. All rights reserved.
FAU - Eng, Hooi Sian
AU  - Eng HS
AD  - Department of Medicine, University of Adelaide, Adelaide, South Australia, 
      Australia.
FAU - Bennett, Greg
AU  - Bennett G
FAU - Chang, Sean H
AU  - Chang SH
FAU - Dent, Hannah
AU  - Dent H
FAU - McDonald, Stephen P
AU  - McDonald SP
FAU - Bardy, Peter
AU  - Bardy P
FAU - Coghlan, Patrick
AU  - Coghlan P
FAU - Russ, Graeme R
AU  - Russ GR
FAU - Coates, P Toby H
AU  - Coates PT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110212
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Biomarkers)
RN  - 0 (HLA Antigens)
RN  - 0 (Isoantibodies)
SB  - IM
MH  - Biomarkers/*blood
MH  - Delayed Graft Function
MH  - Disease Progression
MH  - Follow-Up Studies
MH  - Glomerulonephritis, Membranous
MH  - Graft Rejection/diagnosis/epidemiology/*immunology/mortality/physiopathology
MH  - HLA Antigens/*immunology
MH  - Humans
MH  - Isoantibodies/*blood
MH  - *Kidney Transplantation
MH  - Prognosis
MH  - Risk Factors
MH  - Survival Analysis
EDAT- 2011/02/16 06:00
MHDA- 2011/08/19 06:00
CRDT- 2011/02/16 06:00
PHST- 2010/07/03 00:00 [received]
PHST- 2010/12/30 00:00 [revised]
PHST- 2011/02/03 00:00 [accepted]
PHST- 2011/02/16 06:00 [entrez]
PHST- 2011/02/16 06:00 [pubmed]
PHST- 2011/08/19 06:00 [medline]
AID - S0198-8859(11)00030-9 [pii]
AID - 10.1016/j.humimm.2011.02.002 [doi]
PST - ppublish
SO  - Hum Immunol. 2011 May;72(5):386-91. doi: 10.1016/j.humimm.2011.02.002. Epub 2011 
      Feb 12.