PMID- 21321322
OWN - NLM
STAT- MEDLINE
DCOM- 20110405
LR  - 20131121
IS  - 1535-3699 (Electronic)
IS  - 1535-3699 (Linking)
VI  - 236
IP  - 2
DP  - 2011 Feb
TI  - Suppression of mast-cell-mediated allergic inflammation by Lindera obtusiloba.
PG  - 240-6
LID - 10.1258/ebm.2010.010274 [doi]
AB  - Allergic disease is a consequence of exposure to normally innocuous substances 
      that elicit the activation of mast cells. Mast-cell-mediated allergic response is 
      involved in many diseases such as anaphylaxis, allergic rhinitis, asthma and 
      atopic dermatitis. The discovery of drugs for the treatment of allergic disease 
      is an important subject in human health. In this study, we investigated the 
      effect of Lindera obtusiloba water extract (LOWE) on the mast-cell-mediated 
      allergic inflammation and possible mechanism of action using in vitro and in vivo 
      models. LOWE reduced histamine release from various types of mast cells activated 
      by immunoglobulin E (IgE) or phorbol 12-myristate 13-acetate and calcium 
      ionophore A23187 (PMACI). The inhibitory effect of LOWE on histamine release was 
      mediated by calcium signal. LOWE decreased the PMACI-stimulated gene expression 
      of proinflammatory cytokines such as tumor necrosis factor-alpha and interleukin-6 in 
      human mast cells. The inhibitory effect of LOWE on the proinflammatory cytokines 
      was nuclear factor (NF)-kappaB dependent. In addition, LOWE suppressed compound 
      48/80-induced systemic allergic reaction and serum histamine release in mice and 
      IgE-mediated local allergic reactions. Our results indicate that LOWE inhibits 
      mast-cell-derived allergic inflammation and involvement of calcium, histamine, 
      proinflammatory cytokines and NF-kappaB in these effects.
FAU - Suh, Won Mo
AU  - Suh WM
AD  - College of Pharmacy, Youngnam University, Kyungsan 712-749, South Korea.
FAU - Park, Seung-Bin
AU  - Park SB
FAU - Lee, Soyoung
AU  - Lee S
FAU - Kim, Hui-Hun
AU  - Kim HH
FAU - Suk, Kyoungho
AU  - Suk K
FAU - Son, Jun-Ho
AU  - Son JH
FAU - Kwon, Taeg Kyu
AU  - Kwon TK
FAU - Choi, Hyun Gyu
AU  - Choi HG
FAU - Lee, Seung-Ho
AU  - Lee SH
FAU - Kim, Sang-Hyun
AU  - Kim SH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Exp Biol Med (Maywood)
JT  - Experimental biology and medicine (Maywood, N.J.)
JID - 100973463
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Interleukin-6)
RN  - 0 (Plant Extracts)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 820484N8I3 (Histamine)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Anti-Allergic Agents/*administration & dosage/isolation & 
      purification/pharmacology
MH  - Calcium/metabolism
MH  - Cell Line
MH  - Disease Models, Animal
MH  - Gene Expression
MH  - Histamine/metabolism
MH  - Humans
MH  - Hypersensitivity/*drug therapy
MH  - Inflammation/*prevention & control
MH  - Interleukin-6/antagonists & inhibitors/biosynthesis
MH  - Lindera/*chemistry
MH  - Mast Cells/*drug effects/*immunology
MH  - Mice
MH  - Plant Extracts/*administration & dosage/isolation & purification/pharmacology
MH  - Signal Transduction
MH  - Tumor Necrosis Factor-alpha/antagonists & inhibitors/biosynthesis
EDAT- 2011/02/16 06:00
MHDA- 2011/04/06 06:00
CRDT- 2011/02/16 06:00
PHST- 2011/02/16 06:00 [entrez]
PHST- 2011/02/16 06:00 [pubmed]
PHST- 2011/04/06 06:00 [medline]
AID - 236/2/240 [pii]
AID - 10.1258/ebm.2010.010274 [doi]
PST - ppublish
SO  - Exp Biol Med (Maywood). 2011 Feb;236(2):240-6. doi: 10.1258/ebm.2010.010274.