PMID- 21324622
OWN - NLM
STAT- MEDLINE
DCOM- 20120619
LR  - 20220331
IS  - 1872-7727 (Electronic)
IS  - 0720-048X (Linking)
VI  - 81
IP  - 3
DP  - 2012 Mar
TI  - Influence of left ventricular hypertrophy on infarct size and left ventricular 
      ejection fraction in ST-elevation myocardial infarction.
PG  - e177-81
LID - 10.1016/j.ejrad.2011.01.088 [doi]
AB  - BACKGROUND: Left ventricular hypertrophy (LVH) predisposes to larger infarct 
      size, which may be underestimated by the left ventricular ejection fraction 
      (LVEF) due to supranormal systolic performance often present in patients with 
      LVH. The aim of the study was to compare infarct size and LVEF in patients with 
      ST-segment elevation myocardial infarction (STEMI) and increased left ventricular 
      mass on cardiac magnetic resonance (CMR). METHODS: The study included unselected 
      group of 52 patients (61+/-11 years, 69% male) with first STEMI who had CMR after 
      median 5 days from the onset of the event. Left ventricular hypertrophy (LVH) was 
      defined as left ventricular mass index exceeding 95th percentile of references 
      values for age and gender. Infarct size was assessed with means of late 
      gadolinium enhancement (LGE). RESULTS: LVH was found in 16 patients (31%). In 
      comparison to the rest of the group, patients with LVH had higher absolute and 
      relative infarct mass (p=0.002 and p=0.02, respectively). LVH was related to 
      higher prevalence of microvascular obstruction and myocardial haemorrhage and 
      higher number of LV segments with transmural necrosis (p=0.02, p=0.01 and p=0.01, 
      respectively). Despite marked difference in the infarct size between both studied 
      subgroups there was no difference in LVEF and mean number of dysfunctional LV 
      segments. CONCLUSIONS: Patients with LVH undergoing STEMI have larger infarct 
      size underestimated by the LV systolic performance in comparison to patients 
      without LVH.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Malek, Lukasz A
AU  - Malek LA
AD  - Department of Interventional Cardiology and Angiology, Institute of Cardiology, 
      Alpejska 42, 04-628 Warsaw, Poland.
FAU - Spiewak, Mateusz
AU  - Spiewak M
FAU - Klopotowski, Mariusz
AU  - Klopotowski M
FAU - Petryka, Joanna
AU  - Petryka J
FAU - Mazurkiewicz, Lukasz
AU  - Mazurkiewicz L
FAU - Kruk, Mariusz
AU  - Kruk M
FAU - Kepka, Cezary
AU  - Kepka C
FAU - Misko, Jolanta
AU  - Misko J
FAU - Ruzyllo, Witold
AU  - Ruzyllo W
FAU - Witkowski, Adam
AU  - Witkowski A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110215
PL  - Ireland
TA  - Eur J Radiol
JT  - European journal of radiology
JID - 8106411
RN  - 0 (Biomarkers)
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 1BJ477IO2L (gadobutrol)
SB  - IM
MH  - Biomarkers/analysis
MH  - Chi-Square Distribution
MH  - Comorbidity
MH  - Contrast Media
MH  - Echocardiography
MH  - Electrocardiography
MH  - Female
MH  - Humans
MH  - Hypertrophy, Left Ventricular/*diagnosis/diagnostic imaging/*physiopathology
MH  - Image Interpretation, Computer-Assisted
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/diagnostic imaging/*physiopathology
MH  - Organometallic Compounds
MH  - Risk Factors
MH  - Statistics, Nonparametric
MH  - Stroke Volume/*physiology
EDAT- 2011/02/18 06:00
MHDA- 2012/06/20 06:00
CRDT- 2011/02/18 06:00
PHST- 2010/12/30 00:00 [received]
PHST- 2011/01/20 00:00 [accepted]
PHST- 2011/02/18 06:00 [entrez]
PHST- 2011/02/18 06:00 [pubmed]
PHST- 2012/06/20 06:00 [medline]
AID - S0720-048X(11)00128-8 [pii]
AID - 10.1016/j.ejrad.2011.01.088 [doi]
PST - ppublish
SO  - Eur J Radiol. 2012 Mar;81(3):e177-81. doi: 10.1016/j.ejrad.2011.01.088. Epub 2011 
      Feb 15.