PMID- 21324979
OWN - NLM
STAT- MEDLINE
DCOM- 20120222
LR  - 20211020
IS  - 1462-0332 (Electronic)
IS  - 1462-0324 (Print)
IS  - 1462-0324 (Linking)
VI  - 50
IP  - 7
DP  - 2011 Jul
TI  - Prevalence and correlates of sleep disturbance in systemic sclerosis--results 
      from the UCLA scleroderma quality of life study.
PG  - 1280-7
LID - 10.1093/rheumatology/ker020 [doi]
AB  - OBJECTIVE: Rheumatologic disorders are associated with sleep disturbances. This 
      study examines sleep disturbance correlates in patients with SSc. METHODS: 
      Participants are 180 SSc patients in an observational study. At baseline, 
      patients completed the Medical Outcomes Study Sleep measure (MOS-Sleep scale). In 
      addition, patients were administered other patient-reported outcome (PRO) 
      measures including the 36-item short form (SF-36), HAQ disability index (HAQ-DI), 
      Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue), Center 
      for Epidemiologic Studies Depression (CESD) scale and a University of California 
      at Los Angeles Scleroderma Clinical Trial Consortium Gastrointestinal Tract 
      Questionnaire (UCLA SCTC GIT 2.0). Descriptive statistics were assessed for six 
      scales of MOS-Sleep and the 9-item sleep problem index (SLP-9; a composite 
      index). We computed Spearman's rank-order correlations between the MOS-Sleep 
      scales and the HAQ-DI, FACIT-Fatigue, CESD, SSc-SCTC GIT 2.0 and SF-36 scales. In 
      addition, we developed a regression model to assess predictors of SLP-9 scores. 
      Covariates included demographics, physician variables of disease severity and 
      patient-reported variables of worsening symptoms and the PRO measures. RESULTS: 
      SSc patients reported a mean (s.d.) of 7.1 (1.73) h of sleep a night. Patients 
      reported worse scores on four of six scales (except for snoring and sleep 
      quantity) compared with the US general population (P < 0.001). SLP-9 was 
      correlated with worsening pain and dyspnoea over the past 1 month, reflux scale 
      of the UCLA SCTC GIT 2.0, CESD and FACIT-Fatigue (rho 0.26-0.56). In the stepwise 
      multivariate regression model, the CESD, worsening dyspnoea and reflux scale were 
      significantly associated with SLP-9 index. CONCLUSION: Sleep disturbances are 
      common in SSc and are associated with worsening dyspnoea, depressed mood and 
      severity of reflux symptoms.
FAU - Frech, Tracy
AU  - Frech T
AD  - Department of Internal Medicine, Division of Rheumatology, University of Utah, 
      Salt Lake City, UT , USA.
FAU - Hays, Ron D
AU  - Hays RD
FAU - Maranian, Paul
AU  - Maranian P
FAU - Clements, Philip J
AU  - Clements PJ
FAU - Furst, Daniel E
AU  - Furst DE
FAU - Khanna, Dinesh
AU  - Khanna D
LA  - eng
GR  - K23 AR053858/AR/NIAMS NIH HHS/United States
GR  - K23 AR053858-04/AR/NIAMS NIH HHS/United States
GR  - K23AR053858-04/AR/NIAMS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110215
PL  - England
TA  - Rheumatology (Oxford)
JT  - Rheumatology (Oxford, England)
JID - 100883501
SB  - IM
MH  - Academic Medical Centers
MH  - Age Distribution
MH  - Aged
MH  - Comorbidity
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Los Angeles
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - *Quality of Life
MH  - Regression Analysis
MH  - Scleroderma, Systemic/*diagnosis/*epidemiology
MH  - Severity of Illness Index
MH  - Sex Distribution
MH  - Sickness Impact Profile
MH  - Sleep Wake Disorders/*diagnosis/*epidemiology
PMC - PMC3116211
EDAT- 2011/02/18 06:00
MHDA- 2012/02/23 06:00
PMCR- 2012/07/01
CRDT- 2011/02/18 06:00
PHST- 2011/02/18 06:00 [entrez]
PHST- 2011/02/18 06:00 [pubmed]
PHST- 2012/02/23 06:00 [medline]
PHST- 2012/07/01 00:00 [pmc-release]
AID - ker020 [pii]
AID - 10.1093/rheumatology/ker020 [doi]
PST - ppublish
SO  - Rheumatology (Oxford). 2011 Jul;50(7):1280-7. doi: 10.1093/rheumatology/ker020. 
      Epub 2011 Feb 15.