PMID- 21327958
OWN - NLM
STAT- MEDLINE
DCOM- 20110805
LR  - 20240430
IS  - 1435-5922 (Electronic)
IS  - 0944-1174 (Linking)
VI  - 46
IP  - 4
DP  - 2011 Apr
TI  - Dendritic cells in hepatitis C infection: can they (help) win the battle?
PG  - 432-47
LID - 10.1007/s00535-011-0377-y [doi]
AB  - Infection with hepatitis C virus (HCV) is a public health problem; it establishes 
      a chronic course in ~85% of infected patients and increases their risk for 
      developing liver cirrhosis, hepatocellular carcinoma, and significant 
      extrahepatic manifestations. The mechanisms of HCV persistence remain elusive and 
      are largely related to inefficient clearance of the virus by the host immune 
      system. Dendritic cells (DCs) are the most efficient inducers of immune 
      responses; they are capable of triggering productive immunity and maintaining the 
      state of tolerance to self- and non-self antigens. During the past decade, 
      multiple research groups have focused on DCs, in hopes of unraveling an 
      HCV-specific DC signature or DC-dependent mechanisms of antiviral immunity which 
      would lead to a successful HCV elimination strategy. This review incorporates the 
      latest update in the current status of knowledge on the role of DCs in anti-HCV 
      immunity as it relates to several challenging questions: (a) the phenotype and 
      function of diverse DC subsets in HCV-infected patients; (b) the characteristics 
      of non-human HCV infection models from the DCs' point of view; (c) how can in 
      vitro systems, ranging from HCV protein- or peptide-exposed DC to HCV 
      protein-expressing DCs, and in vivo systems, ranging from HCV protein-expressing 
      transgenic mice to HCV-infected non-human primates, be employed to dissect the 
      role of DCs in triggering/maintaining a robust antiviral response; and (d) the 
      prospect of DC-based strategy for managing and finding a cure for HCV infection.
FAU - Dolganiuc, Angela
AU  - Dolganiuc A
AD  - Department of Medicine, University of Massachusetts Medical School, 364 
      Plantation Street, LRB-270-H, Worcester, MA 01605, USA. 
      angela.dolganiuc@umassmed.edu
FAU - Szabo, Gyongyi
AU  - Szabo G
LA  - eng
GR  - R37 AA014372/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20110217
PL  - Japan
TA  - J Gastroenterol
JT  - Journal of gastroenterology
JID - 9430794
RN  - 0 (Antiviral Agents)
RN  - 0 (Viral Proteins)
SB  - IM
MH  - Animals
MH  - Antiviral Agents/therapeutic use
MH  - Dendritic Cells/*immunology
MH  - Disease Models, Animal
MH  - Hepacivirus/*immunology
MH  - Hepatitis C/*immunology/prevention & control/therapy
MH  - Humans
MH  - Mice
MH  - Viral Proteins/immunology
EDAT- 2011/02/18 06:00
MHDA- 2011/08/06 06:00
CRDT- 2011/02/18 06:00
PHST- 2010/11/10 00:00 [received]
PHST- 2010/12/13 00:00 [accepted]
PHST- 2011/02/18 06:00 [entrez]
PHST- 2011/02/18 06:00 [pubmed]
PHST- 2011/08/06 06:00 [medline]
AID - 10.1007/s00535-011-0377-y [doi]
PST - ppublish
SO  - J Gastroenterol. 2011 Apr;46(4):432-47. doi: 10.1007/s00535-011-0377-y. Epub 2011 
      Feb 17.