PMID- 21329554
OWN - NLM
STAT- MEDLINE
DCOM- 20111027
LR  - 20191210
IS  - 1469-5111 (Electronic)
IS  - 1461-1457 (Linking)
VI  - 14
IP  - 6
DP  - 2011 Jul
TI  - Disruption of prepulse inhibition by 3,4-methylenedioxymethamphetamine (MDMA): 
      comparison between male and female wild-type and 5-HT(1A) receptor knockout mice.
PG  - 856-61
LID - 10.1017/S1461145711000101 [doi]
AB  - The aim of this study was to investigate the involvement of serotonin-1A 
      (5-HT(1A)) receptors in the effects of 3,4-methylenedioxymetamphetamine (MDMA) on 
      prepulse inhibition of acoustic startle (PPI) by comparing male and female 
      wild-type (WT) mice and 5-HT(1A) receptor knockout (1AKO) mice. MDMA 
      dose-dependently decreased PPI in male and female mice although female mice were 
      more sensitive at the 100-ms inter-stimulus interval (ISI). In male mice, 10 
      mg/kg MDMA disrupted PPI in 1AKO but not in WT controls. There was no genotype 
      difference at higher or lower doses of MDMA. In female mice, there was no 
      difference between genotypes at any dose of MDMA. Average startle was reduced by 
      10 mg/kg and 20 mg/kg MDMA similarly in male and female mice and all genotypes. 
      These results show an involvement of 5-HT(1A) receptors in the effect of MDMA on 
      PPI in male, but not female mice.
FAU - van den Buuse, Maarten
AU  - van den Buuse M
AD  - Behavioural Neuroscience Laboratory, Mental Health Research Institute, Melbourne, 
      Victoria, Australia. m.vandenbuuse@mhri.edu.au
FAU - Becker, Thorsten
AU  - Becker T
FAU - Kwek, Perrin
AU  - Kwek P
FAU - Martin, Sally
AU  - Martin S
FAU - Ruimschotel, Emma
AU  - Ruimschotel E
FAU - Risbrough, Victoria
AU  - Risbrough V
LA  - eng
GR  - R01 DA002925-27/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110218
PL  - England
TA  - Int J Neuropsychopharmacol
JT  - The international journal of neuropsychopharmacology
JID - 9815893
RN  - 0 (Adrenergic Uptake Inhibitors)
RN  - 0 (Hallucinogens)
RN  - 0 (Illicit Drugs)
RN  - 112692-38-3 (Receptor, Serotonin, 5-HT1A)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/administration & dosage/*toxicity
MH  - Acoustic Stimulation
MH  - Adrenergic Uptake Inhibitors/administration & dosage/toxicity
MH  - Animals
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Hallucinogens/administration & dosage/*toxicity
MH  - Heterozygote
MH  - Illicit Drugs/toxicity
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Neural Inhibition/*drug effects
MH  - Receptor, Serotonin, 5-HT1A/genetics/*physiology
MH  - Reflex, Startle/drug effects
MH  - Sex Characteristics
EDAT- 2011/02/19 06:00
MHDA- 2011/10/28 06:00
CRDT- 2011/02/19 06:00
PHST- 2011/02/19 06:00 [entrez]
PHST- 2011/02/19 06:00 [pubmed]
PHST- 2011/10/28 06:00 [medline]
AID - S1461145711000101 [pii]
AID - 10.1017/S1461145711000101 [doi]
PST - ppublish
SO  - Int J Neuropsychopharmacol. 2011 Jul;14(6):856-61. doi: 
      10.1017/S1461145711000101. Epub 2011 Feb 18.