PMID- 21329899
OWN - NLM
STAT- MEDLINE
DCOM- 20110613
LR  - 20220331
IS  - 1876-7591 (Electronic)
IS  - 1876-7591 (Linking)
VI  - 4
IP  - 2
DP  - 2011 Feb
TI  - Evaluation of techniques for the quantification of myocardial scar of differing 
      etiology using cardiac magnetic resonance.
PG  - 150-6
LID - 10.1016/j.jcmg.2010.11.015 [doi]
AB  - OBJECTIVES: The aim of this study was to compare the reproducibility of 7 late 
      gadolinium enhancement (LGE) quantification techniques across 3 conditions in 
      which LGE is known to be important: acute myocardial infarction (AMI), chronic 
      myocardial infarction (CMI), and hypertrophic cardiomyopathy (HCM). BACKGROUND: 
      LGE by cardiac magnetic resonance is the gold-standard technique for assessing 
      myocardial scar. No consensus exists on the best method for its quantification, 
      and research in this area is scant. Techniques include manual quantification, 
      thresholding by 2, 3, 4, 5, or 6 SDs above remote myocardium, and the full width 
      at half maximum (FWHM) technique. To date, LGE has been linked to outcome in 3 
      conditions: AMI, CMI, and HCM. METHODS: Sixty patients with 3 LGE etiologies 
      (AMI, n = 20; CMI, n = 20; HCM, n = 20) were scanned for LGE. LGE volume was 
      quantified using the 7 techniques. Mean LGE volume, interobserver and 
      intraobserver reproducibility, and impact on sample size were assessed. RESULTS: 
      LGE volume varied significantly with the quantification method used. There was no 
      statistically significant difference between LGE volume by the FWHM, manual, and 
      6-SD or 5-SD techniques. The 2-SD technique generated LGE volumes up to 2 times 
      higher than the FWHM, 6-SD, and manual techniques. The reproducibility of all 
      techniques was worse in HCM than AMI or CMI. The FWHM technique was the most 
      reproducible in all 3 conditions compared with any other method (p < 0.001). Use 
      of the FWHM technique for LGE quantification in paired analysis would lead to at 
      least a 60% reduction in required sample size compared with any other method. 
      CONCLUSIONS: Regardless of the disease under study, the FWHM technique for LGE 
      quantification gives LGE volume mean results similar to manual quantification and 
      is statistically the most reproducible, reducing required sample sizes by up to 
      one-half.
CI  - Copyright (c) 2011 American College of Cardiology Foundation. Published by Elsevier 
      Inc. All rights reserved.
FAU - Flett, Andrew S
AU  - Flett AS
AD  - Department of Cardiology, The Heart Hospital, University College London Hospitals 
      NHS Trust, London, UK.
FAU - Hasleton, Jonathan
AU  - Hasleton J
FAU - Cook, Christopher
AU  - Cook C
FAU - Hausenloy, Derek
AU  - Hausenloy D
FAU - Quarta, Giovanni
AU  - Quarta G
FAU - Ariti, Cono
AU  - Ariti C
FAU - Muthurangu, Vivek
AU  - Muthurangu V
FAU - Moon, James C
AU  - Moon JC
LA  - eng
GR  - FS/08/012/24454/BHF_/British Heart Foundation/United Kingdom
GR  - FS/08/028/24767/BHF_/British Heart Foundation/United Kingdom
GR  - FS/10/72/28568/BHF_/British Heart Foundation/United Kingdom
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - JACC Cardiovasc Imaging
JT  - JACC. Cardiovascular imaging
JID - 101467978
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 6HG8UB2MUY (Meglumine)
RN  - L0ND3981AG (gadoterate meglumine)
SB  - IM
CIN - JACC Cardiovasc Imaging. 2011 Feb;4(2):157-60. PMID: 21329900
CIN - JACC Cardiovasc Imaging. 2011 Nov;4(11):1223; author reply 1224. PMID: 22093276
MH  - Adult
MH  - Aged
MH  - Cardiomyopathy, Hypertrophic/complications/*diagnosis/pathology
MH  - Cicatrix/*diagnosis/etiology/pathology
MH  - Contrast Media
MH  - Female
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - London
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Meglumine
MH  - Middle Aged
MH  - Myocardial Infarction/complications/*diagnosis/pathology
MH  - Myocardium/*pathology
MH  - Observer Variation
MH  - Organometallic Compounds
MH  - Predictive Value of Tests
MH  - Reproducibility of Results
MH  - Retrospective Studies
EDAT- 2011/02/19 06:00
MHDA- 2011/06/15 06:00
CRDT- 2011/02/19 06:00
PHST- 2010/09/08 00:00 [received]
PHST- 2010/10/26 00:00 [revised]
PHST- 2010/11/22 00:00 [accepted]
PHST- 2011/02/19 06:00 [entrez]
PHST- 2011/02/19 06:00 [pubmed]
PHST- 2011/06/15 06:00 [medline]
AID - S1936-878X(10)00837-5 [pii]
AID - 10.1016/j.jcmg.2010.11.015 [doi]
PST - ppublish
SO  - JACC Cardiovasc Imaging. 2011 Feb;4(2):150-6. doi: 10.1016/j.jcmg.2010.11.015.