PMID- 21330616
OWN - NLM
STAT- MEDLINE
DCOM- 20140404
LR  - 20220409
IS  - 1522-1601 (Electronic)
IS  - 8750-7587 (Print)
IS  - 0161-7567 (Linking)
VI  - 110
IP  - 6
DP  - 2011 Jun
TI  - Diverse patterns of myocardial fibrosis in lifelong, veteran endurance athletes.
PG  - 1622-6
LID - 10.1152/japplphysiol.01280.2010 [doi]
AB  - This study examined the cardiac structure and function of a unique cohort of 
      documented lifelong, competitive endurance veteran athletes (>50 yr). Twelve 
      lifelong veteran male endurance athletes [mean +/- SD (range) age: 56 +/- 6 yr 
      (50-67)], 20 age-matched veteran controls [60 +/- 5 yr; (52-69)], and 17 younger 
      male endurance athletes [31 +/- 5 yr (26-40)] without significant comorbidities 
      underwent cardiac magnetic resonance (CMR) imaging to assess cardiac morphology 
      and function, as well as CMR imaging with late gadolinium enhancement (LGE) to 
      assess myocardial fibrosis. Lifelong veteran athletes had smaller left (LV) and 
      right ventricular (RV) end-diastolic and end-systolic volumes (P < 0.05), but 
      maintained LV and RV systolic function compared with young athletes. However, 
      veteran athletes had a significantly larger absolute and indexed LV and RV 
      end-diastolic and systolic volumes, intraventricular septum thickness during 
      diastole, posterior wall thickness during diastole, and LV and RV stroke volumes 
      (P < 0.05), together with significantly reduced LV and RV ejection fractions (P < 
      0.05), compared with veteran controls. In six (50%) of the veteran athletes, LGE 
      of CMR indicated the presence of myocardial fibrosis (4 veteran athletes with LGE 
      of nonspecific cause, 1 probable previous myocarditis, and 1 probable previous 
      silent myocardial infarction). There was no LGE in the age-matched veteran 
      controls or young athletes. The prevalence of LGE in veteran athletes was not 
      associated with age, height, weight, or body surface area (P > 0.05), but was 
      significantly associated with the number of years spent training (P < 0.001), 
      number of competitive marathons (P < 0.001), and ultraendurance (>50 miles) 
      marathons (P < 0.007) completed. An unexpectedly high prevalence of myocardial 
      fibrosis (50%) was observed in healthy, asymptomatic, lifelong veteran male 
      athletes, compared with zero cases in age-matched veteran controls and young 
      athletes. These data suggest a link between lifelong endurance exercise and 
      myocardial fibrosis that requires further investigation.
FAU - Wilson, M
AU  - Wilson M
AD  - ASPETAR, Qatar Orthopaedic and Sports Medicine Hospital, PO Box 29222, Doha, 
      Qatar. Mathew.wilson@aspetar.com
FAU - O'Hanlon, R
AU  - O'Hanlon R
FAU - Prasad, S
AU  - Prasad S
FAU - Deighan, A
AU  - Deighan A
FAU - Macmillan, P
AU  - Macmillan P
FAU - Oxborough, D
AU  - Oxborough D
FAU - Godfrey, R
AU  - Godfrey R
FAU - Smith, G
AU  - Smith G
FAU - Maceira, A
AU  - Maceira A
FAU - Sharma, S
AU  - Sharma S
FAU - George, K
AU  - George K
FAU - Whyte, G
AU  - Whyte G
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20110217
PL  - United States
TA  - J Appl Physiol (1985)
JT  - Journal of applied physiology (Bethesda, Md. : 1985)
JID - 8502536
RN  - 0 (Contrast Media)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aging
MH  - Analysis of Variance
MH  - *Athletes
MH  - Case-Control Studies
MH  - Contrast Media
MH  - England
MH  - Fibrosis
MH  - Heart Diseases/*pathology/physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*pathology
MH  - *Physical Endurance
MH  - Stroke Volume
MH  - Systole
MH  - Ventricular Function, Left
MH  - Ventricular Function, Right
PMC - PMC3119133
EDAT- 2011/02/19 06:00
MHDA- 2014/04/05 06:00
PMCR- 2012/06/01
CRDT- 2011/02/19 06:00
PHST- 2011/02/19 06:00 [entrez]
PHST- 2011/02/19 06:00 [pubmed]
PHST- 2014/04/05 06:00 [medline]
PHST- 2012/06/01 00:00 [pmc-release]
AID - japplphysiol.01280.2010 [pii]
AID - JAPPL-01280-2010 [pii]
AID - 10.1152/japplphysiol.01280.2010 [doi]
PST - ppublish
SO  - J Appl Physiol (1985). 2011 Jun;110(6):1622-6. doi: 
      10.1152/japplphysiol.01280.2010. Epub 2011 Feb 17.