PMID- 21331295
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 2090-0716 (Electronic)
IS  - 2090-0708 (Print)
IS  - 2090-0708 (Linking)
VI  - 2011
DP  - 2011
TI  - Continuous glucose monitoring for evaluation of glycemic excursions after gastric 
      bypass.
PG  - 869536
LID - 10.1155/2011/869536 [doi]
LID - 869536
AB  - Background. Hyperinsulinemic hypoglycemia with neuroglycopenia is a rare 
      complication of Roux-en-Y gastric bypass (RYGB). We hypothesized that continuous 
      glucose monitoring (CGM) would be useful to characterize glycemic variability 
      after RYGB. Methods. CGM and mixed meal tolerance testing (MMTT) were performed 
      on sixteen post-RYGB subjects, ten with a history of neuroglycopenia on medical 
      treatment and six asymptomatic controls. Results. 9 of 10 subjects with 
      neuroglycopenia developed hypoglycemia defined by glucose <70 mg/dL on CGM, and 3 
      of 9 on MMTT. In asymptomatic subjects, 3 of 6 had asymptomatic hypoglycemia 
      during CGM, and 3 of 5 on MMTT. Therefore, the sensitivity and specificity to 
      detect clinically significant hypoglycemia was 90% and 50% for CGM and 33% and 
      40% for MMTT. Conclusions. Asymptomatic hypoglycemia after RYGB is more frequent 
      than commonly recognized. For clinicians evaluating patients for postbypass 
      neuroglycopenia, CGM may be a valuable diagnostic tool.
FAU - Halperin, Florencia
AU  - Halperin F
AD  - Brigham and Women's Hospital, Boston 02115, MA, USA.
FAU - Patti, Mary Elizabeth
AU  - Patti ME
FAU - Skow, Megan
AU  - Skow M
FAU - Bajwa, Muhammad
AU  - Bajwa M
FAU - Goldfine, Allison B
AU  - Goldfine AB
LA  - eng
GR  - P30 DK036836/DK/NIDDK NIH HHS/United States
GR  - RC1 DK086918/DK/NIDDK NIH HHS/United States
GR  - UL1 RR025758/RR/NCRR NIH HHS/United States
PT  - Journal Article
DEP - 20110207
PL  - United States
TA  - J Obes
JT  - Journal of obesity
JID - 101526295
PMC - PMC3038694
EDAT- 2011/02/19 06:00
MHDA- 2011/02/19 06:01
PMCR- 2011/02/07
CRDT- 2011/02/19 06:00
PHST- 2010/11/04 00:00 [received]
PHST- 2011/01/13 00:00 [accepted]
PHST- 2011/02/19 06:00 [entrez]
PHST- 2011/02/19 06:00 [pubmed]
PHST- 2011/02/19 06:01 [medline]
PHST- 2011/02/07 00:00 [pmc-release]
AID - 10.1155/2011/869536 [doi]
PST - ppublish
SO  - J Obes. 2011;2011:869536. doi: 10.1155/2011/869536. Epub 2011 Feb 7.