PMID- 21331390
OWN - NLM
STAT- MEDLINE
DCOM- 20111206
LR  - 20191210
IS  - 1364-5528 (Electronic)
IS  - 0003-2654 (Linking)
VI  - 136
IP  - 17
DP  - 2011 Sep 7
TI  - Determination of amphetamine-type stimulants, cocaine and ketamine in human hair 
      by liquid chromatography/linear ion trap-Orbitrap hybrid mass spectrometry.
PG  - 3503-11
LID - 10.1039/c0an00850h [doi]
AB  - An LTQ Orbitrap XL hybrid mass spectrometry method was developed for the 
      determination of illicit drugs and their metabolites, including amphetamine (AP), 
      methamphetamine (MA), dimethylamphetamine (DMA), 3,4-methylenedioxyamphetamine 
      (MDA), 3,4-methylenedioxymethamphetamine (MDMA), ketamine (KET), norketamine 
      (NK), cocaine (COC) and benzoylecgonine (BE), in hair. Micropulverized extraction 
      was employed for sample preparation using a small hair sample (2 cm piece or 0.2 
      mg). Recoveries of the analytes during sample preparation were estimated using 
      fortified hair samples and ranged from 35.5% for COC to 71.7% for AP. High 
      resolution full-scan mass spectra and unit resolution product-ion spectra were 
      obtained with the Orbitrap analyzer and the linear ion-trap analyzer, 
      respectively. High-resolution extracted ion chromatograms at a tolerance of 3 ppm 
      were utilized for quantification. The analytes were identified using the 
      product-ion spectra in combination with the accurate masses of the corresponding 
      protonated molecules observed in the high-resolution mass spectra. Lower limits 
      of quantification obtained from a 0.2 mg hair sample were 0.050 ng mg(-1) (MDMA, 
      KET and BE), 0.10 ng mg(-1) (AP, MA, DMA, NK and COC) and 0.50 ng mg(-1) (MDA). 
      Two reference materials were analyzed for verification, and segmental analysis of 
      single strands of hair specimens from actual cases was performed.
FAU - Miyaguchi, Hajime
AU  - Miyaguchi H
AD  - National Research Institute of Police Science, 6-3-1 Kashiwanoha, Kashiwa, Chiba 
      277-0882, Japan. miyaguchi@nrips.go.jp
FAU - Inoue, Hiroyuki
AU  - Inoue H
LA  - eng
PT  - Journal Article
PT  - Validation Study
DEP - 20110217
PL  - England
TA  - Analyst
JT  - The Analyst
JID - 0372652
RN  - 0 (Amphetamines)
RN  - 0 (Illicit Drugs)
RN  - 44RAL3456C (Methamphetamine)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - 5353I8I6YS (benzoylecgonine)
RN  - 690G0D6V8H (Ketamine)
RN  - I5Y540LHVR (Cocaine)
RN  - IYE3F3MHCU (dimethylamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - XQY6JVF94X (norketamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/analysis
MH  - Amphetamines/*analysis
MH  - Chromatography, Liquid/methods
MH  - Cocaine/analogs & derivatives/*analysis
MH  - Hair/*chemistry
MH  - Humans
MH  - Illicit Drugs/*analysis
MH  - Ketamine/analogs & derivatives/*analysis
MH  - Limit of Detection
MH  - Methamphetamine/analogs & derivatives/analysis
MH  - N-Methyl-3,4-methylenedioxyamphetamine/analysis
MH  - Tandem Mass Spectrometry/*methods
EDAT- 2011/02/19 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/02/19 06:00
PHST- 2011/02/19 06:00 [entrez]
PHST- 2011/02/19 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1039/c0an00850h [doi]
PST - ppublish
SO  - Analyst. 2011 Sep 7;136(17):3503-11. doi: 10.1039/c0an00850h. Epub 2011 Feb 17.