PMID- 21331684
OWN - NLM
STAT- MEDLINE
DCOM- 20110506
LR  - 20211020
IS  - 1613-2246 (Electronic)
IS  - 0021-5155 (Linking)
VI  - 55
IP  - 1
DP  - 2011 Jan
TI  - Inner retinal changes in acute-phase Vogt-Koyanagi-Harada disease measured by 
      enhanced spectral domain optical coherence tomography.
PG  - 1-6
LID - 10.1007/s10384-010-0900-3 [doi]
AB  - PURPOSE: To assess the changes of inner retinal thickness in patients with 
      Vogt-Koyanagi-Harada disease (VKH) using enhanced spectral domain optical 
      coherence tomography (SD-OCT). METHODS: We retrospectively reviewed enhanced 
      SD-OCT images of 12 eyes of seven consecutive patients with VKH in both acute and 
      convalescent phases. Inner retinal thickness, measured from the inner limiting 
      membrane to the inner plexiform layer (ILM-IPL), and nerve fiber layer (NFL) 
      thickness at 1.5 and 2.0 mm along the outer border of the IPL from the central 
      fovea at nasal, temporal, superior, and inferior points were measured. Twelve 
      eyes of 12 patients with central serous chorioretinopathy (CSC) were evaluated as 
      controls. RESULTS: In the VKH patients, ILM-IPL thickness in the acute phase was 
      significantly greater than that in the convalescent phase at each point of the 
      retina; however, an intraretinal cystoid space was not observed. The thickness of 
      the NFL was significantly larger in the nasal quadrant. On fluorescein 
      angiography, no leakage from the retinal vasculature was seen in any of the 
      cases. In the CSC cases, no differences were seen in ILM-IPL thickness between 
      the acute and convalescent phases at any point. CONCLUSIONS: Inner retinal 
      thickness in the acute phase of VKH is larger than in the convalescent phase.
CI  - (c) Japanese Ophthalmological Society 2011.
FAU - Yamamoto, Motoshi
AU  - Yamamoto M
AD  - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School 
      of Medicine, Kyoto, Japan.
FAU - Nishijima, Kazuaki
AU  - Nishijima K
FAU - Nakamura, Misako
AU  - Nakamura M
FAU - Yoshimura, Nagahisa
AU  - Yoshimura N
LA  - eng
PT  - Journal Article
DEP - 20110218
PL  - Japan
TA  - Jpn J Ophthalmol
JT  - Japanese journal of ophthalmology
JID - 0044652
RN  - 0 (Glucocorticoids)
RN  - 9PHQ9Y1OLM (Prednisolone)
RN  - X4W7ZR7023 (Methylprednisolone)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Female
MH  - Fluorescein Angiography
MH  - Glucocorticoids/administration & dosage
MH  - Humans
MH  - Infusions, Intravenous
MH  - Laser Coagulation
MH  - Male
MH  - Methylprednisolone/administration & dosage
MH  - Middle Aged
MH  - Prednisolone/administration & dosage
MH  - Retina/*pathology
MH  - Retinal Diseases/*diagnosis/drug therapy
MH  - Retrospective Studies
MH  - *Tomography, Optical Coherence
MH  - Uveomeningoencephalitic Syndrome/*diagnosis/drug therapy
MH  - Young Adult
EDAT- 2011/02/19 06:00
MHDA- 2011/05/07 06:00
CRDT- 2011/02/19 06:00
PHST- 2010/03/10 00:00 [received]
PHST- 2010/08/23 00:00 [accepted]
PHST- 2011/02/19 06:00 [entrez]
PHST- 2011/02/19 06:00 [pubmed]
PHST- 2011/05/07 06:00 [medline]
AID - 10.1007/s10384-010-0900-3 [doi]
PST - ppublish
SO  - Jpn J Ophthalmol. 2011 Jan;55(1):1-6. doi: 10.1007/s10384-010-0900-3. Epub 2011 
      Feb 18.