PMID- 21331905
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20110218
IS  - 1543-1894 (Print)
IS  - 1543-1894 (Linking)
VI  - 24
DP  - 2000
TI  - Antiviral screening assays for human herpesviruses 6 and 7.
PG  - 129-38
LID - 10.1385/1-59259-245-7:129 [doi]
AB  - Human herpesviruses 6 and 7 are ubiquitous herpesviruses that normally infect 
      their hosts early in life. There are two variant groups of human herpesvirus 6 
      (HHV-6): variants A (HHV-6A) and B (HHV-6B). Variant A has not been unambiguously 
      associated with a specific disease but may contribute to disease in 
      immunocompromised patients; variant B is the major etiologic agent of roseola 
      (roseola infantum or exanthem subitum) and other febrile illnesses of young 
      children, and has been associated with disease in immunocompromised patients. 
      HHV-6B is frequently present in plaque regions in the brains of multiple 
      sclerosis patients, although an etiologic association has not been proven. Human 
      herpesvirus 7 (HHV-7) has been associated with some cases of roseola. The 
      clinical spectrum of these viruses remains to be completely defined. Braun et al. 
      (1) recently described three clinical scenarios that might warrant the use of 
      antivirals to treat HHV-6 infections: (1) transplant recipients with idiopathic 
      pneumonitis (2), multiple sclerosis patients, and (3) patients with 
      HHV-6-associated encephalitis. For HHV-7, cases of neurologic involvement during 
      primary infection might warrant investigation (2).
FAU - Black, J B
AU  - Black JB
AD  - Centers for Disease Control and Prevention, Atlanta, GA.
FAU - Pellett, P E
AU  - Pellett PE
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Methods Mol Med
JT  - Methods in molecular medicine
JID - 101123138
EDAT- 2000/01/01 00:00
MHDA- 2000/01/01 00:01
CRDT- 2011/02/19 06:00
PHST- 2011/02/19 06:00 [entrez]
PHST- 2000/01/01 00:00 [pubmed]
PHST- 2000/01/01 00:01 [medline]
AID - 10.1385/1-59259-245-7:129 [doi]
PST - ppublish
SO  - Methods Mol Med. 2000;24:129-38. doi: 10.1385/1-59259-245-7:129.