PMID- 21332388
OWN - NLM
STAT- MEDLINE
DCOM- 20110923
LR  - 20231213
IS  - 1557-7430 (Electronic)
IS  - 1044-5498 (Linking)
VI  - 30
IP  - 8
DP  - 2011 Aug
TI  - Lack of association between human leukocyte antigen-E alleles and nasopharyngeal 
      carcinoma in Tunisians.
PG  - 603-9
LID - 10.1089/dna.2010.1140 [doi]
AB  - Nasopharyngeal carcinoma (NPC), a cancer with a remarkable geographical and 
      worldwide ethnic distribution, has been strongly associated with human leukocyte 
      antigen (HLA) class I genes. The presence of additional HLA risk factors has been 
      suggested by several reports. In the present study, we analyzed the implication 
      of HLA-E gene polymorphisms in NPC susceptibility in Tunisians, a population 
      characterized by an intermediate incidence of NPC with specific clinical 
      features. Peripheral blood DNA was obtained from 185 patients with NPC and 177 
      matched controls. Genotyping for three single-nucleotide polymorphisms, codon 
      83Gly/Arg, codon 157Arg/Gly, and codon 107Arg/Gly, was performed using the 
      polymerase chain reaction method. The HLA-E*01:01 and HLA-E*01:03 were the only 
      alleles found among Tunisians. The HLA-E*01:03 allele had a slight increase in 
      patients with NPC (43%) compared with controls (37%), but the difference did not 
      reach a statistical significance. Our results show the lack of association 
      between HLA-E alleles and NPC in the Tunisian population. This is not in 
      agreement with the previous studies, suggesting a potential implication of HLA-E 
      gene polymorphisms in the susceptibility to NPC among populations with high-risk 
      incidence. Our study further supports the dissimilarity of NPC between 
      populations with different NPC incidence.
FAU - Hassen, Elham
AU  - Hassen E
AD  - Molecular Immuno-Oncology Laboratory, Faculty of Medicine, Monastir University, 
      Monastir, Tunisia. elham.hassen@isbm.rnu.tn
FAU - Ghedira, Randa
AU  - Ghedira R
FAU - Ghandri, Nahla
AU  - Ghandri N
FAU - Farhat, Karim
AU  - Farhat K
FAU - Gabbouj, Sallouha
AU  - Gabbouj S
FAU - Bouaouina, Noureddine
AU  - Bouaouina N
FAU - Abdelaziz, Hamdi
AU  - Abdelaziz H
FAU - Nouri, Abdelatif
AU  - Nouri A
FAU - Chouchane, Lotfi
AU  - Chouchane L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110220
PL  - United States
TA  - DNA Cell Biol
JT  - DNA and cell biology
JID - 9004522
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Alleles
MH  - Black People/*genetics
MH  - Case-Control Studies
MH  - Child
MH  - Female
MH  - Genetic Predisposition to Disease/genetics
MH  - HLA Antigens/*genetics
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nasopharyngeal Neoplasms/*genetics
MH  - Polymorphism, Genetic
MH  - Tunisia/ethnology
MH  - Young Adult
MH  - HLA-E Antigens
EDAT- 2011/02/22 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/02/22 06:00
PHST- 2011/02/22 06:00 [entrez]
PHST- 2011/02/22 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - 10.1089/dna.2010.1140 [doi]
PST - ppublish
SO  - DNA Cell Biol. 2011 Aug;30(8):603-9. doi: 10.1089/dna.2010.1140. Epub 2011 Feb 
      20.