PMID- 21336871
OWN - NLM
STAT- MEDLINE
DCOM- 20120307
LR  - 20211020
IS  - 1436-6215 (Electronic)
IS  - 1436-6207 (Linking)
VI  - 50
IP  - 8
DP  - 2011 Dec
TI  - A role for suppressed bone formation favoring catch-up fat in the pathophysiology 
      of catch-up growth after food restriction.
PG  - 645-55
LID - 10.1007/s00394-011-0174-7 [doi]
AB  - PURPOSE: Catch-up growth is always companied with later development of obesity 
      and osteoporosis that are two interrelated clinical entities. However, the 
      potential mechanism of the link between them during catch-up growth is unknown. 
      METHODS: Rats were divided into two groups. Rats of the normal control (NC) group 
      were offered ad libitum access to food, while rats of CUGFR group were food 
      restricted for 4 weeks, and then were allowed full access to food for 0, 2, 4 
      weeks, respectively. The fat percentage and distribution, bone mineral density, 
      biochemical and histological indexes of bone were detected. Moreover, the 
      expression of adipogenic or osteoblastic differentiation-related genes of 
      mesenchymal stem cells (MSCs) was also determined. RESULTS: Catch-up growth led 
      to a rapid visceral fat accumulation. Although there was no difference in the 
      histological indexes of bone between NC group and CUGFR group, the bone turnover 
      marker, serum Bone Gla-protein (s-BGP), decreased in CUGFR group. The adipogenic 
      differentiation-related gene of MSCs, PPAR-gamma, was significantly higher than 
      that of NC group especially when catch-up growth for 4 weeks. Nevertheless, the 
      osteoblastic differentiation-related gene of MSCs, Runx2, was increased but 
      failed to reach the levels of the controls eventually. Both protein and mRNA of 
      TAZ, a main transcriptional modulator of MSCs differentiation, failed to catch up 
      even after being allowed full access to food for 4 weeks. CONCLUSION: CUGFR 
      induces the differential differentiation of MSCs, potentially suppressing bone 
      formation and favoring catch-up fat, which might be responsible for the increased 
      risk of osteoporosis and obesity during CUGFR.
FAU - Guo, Xiangfei
AU  - Guo X
AD  - Department of Pain, Xuanwu Hospital, Capital Medical University, 100053, Beijing, 
      China.
FAU - Yang, Weihong
AU  - Yang W
FAU - Ni, Jiaxiang
AU  - Ni J
FAU - He, Mingwei
AU  - He M
FAU - Yang, Liqiang
AU  - Yang L
LA  - eng
PT  - Journal Article
DEP - 20110219
PL  - Germany
TA  - Eur J Nutr
JT  - European journal of nutrition
JID - 100888704
RN  - 0 (Core Binding Factor Alpha 1 Subunit)
RN  - 0 (Fats)
RN  - 0 (PPAR gamma)
RN  - 0 (RNA, Messenger)
RN  - 0 (Runx2 protein, rat)
RN  - 104982-03-8 (Osteocalcin)
SB  - IM
MH  - Adipogenesis
MH  - Animals
MH  - Body Fat Distribution
MH  - Bone Density
MH  - *Caloric Restriction
MH  - Core Binding Factor Alpha 1 Subunit/genetics/metabolism
MH  - Fats/metabolism
MH  - Male
MH  - Mesenchymal Stem Cells/cytology/*metabolism
MH  - Models, Animal
MH  - Obesity/*physiopathology
MH  - Osteocalcin/genetics/metabolism
MH  - *Osteogenesis
MH  - Osteoporosis/*physiopathology
MH  - PPAR gamma/genetics/metabolism
MH  - RNA, Messenger
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2011/02/22 06:00
MHDA- 2012/03/08 06:00
CRDT- 2011/02/22 06:00
PHST- 2010/11/28 00:00 [received]
PHST- 2011/01/27 00:00 [accepted]
PHST- 2011/02/22 06:00 [entrez]
PHST- 2011/02/22 06:00 [pubmed]
PHST- 2012/03/08 06:00 [medline]
AID - 10.1007/s00394-011-0174-7 [doi]
PST - ppublish
SO  - Eur J Nutr. 2011 Dec;50(8):645-55. doi: 10.1007/s00394-011-0174-7. Epub 2011 Feb 
      19.