PMID- 21337348
OWN - NLM
STAT- MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1932-8737 (Electronic)
IS  - 0160-9289 (Print)
IS  - 0160-9289 (Linking)
VI  - 34
IP  - 3
DP  - 2011 Mar
TI  - High white blood cell count and low estimated glomerular filtration rate are 
      independently associated with serum level of monocyte chemoattractant protein-1 
      in a general population.
PG  - 189-94
LID - 10.1002/clc.20834 [doi]
AB  - BACKGROUND: Monocyte chemoattractant protein-1 (MCP-1) plays a role in 
      cardiovascular disease (CVD) and renal injury. Recent clinical studies have 
      suggested that circulating levels of MCP-1 could be a biomarker of 
      atherosclerosis and future cardiovascular events in humans. Because chronic 
      kidney disease (CKD) is one of the risk factors of CVD, it is conceivable that 
      elevated MCP-1 levels may link the increased risk of CVD in CKD patients. 
      However, as far as we know, in addition to well-known traditional risk factors 
      for atherosclerosis, whether renal dysfunction could be independently associated 
      with the elevation of MCP-1 levels in a general population remains unknown. 
      Therefore, we examined here which anthropometric and metabolic variables, 
      including renal function, could be independent correlates of circulating levels 
      of MCP-1 in a general population. HYPOTHESIS: We hypothesized that renal function 
      was one of the independent correlates of serum MCP-1 levels. METHODS: A total of 
      860 Japanese residents (318 males and 542 females, mean age 65.4 +/- 9.8 years) in 
      a small fishing community underwent a complete history and physical examination 
      with determination of blood chemistries, including serum levels of MCP-1. 
      RESULTS: Mean MCP-1 levels were 281.4 pg/mL. Multiple stepwise regression 
      analyses revealed that male sex (P<0.0001), age (P=0.03), estimated glomerular 
      filtration rate (eGFR) (P<0.0001, inversely), and white blood cell count 
      (P=0.037) were independently associated with MCP-1 levels. CONCLUSIONS: The 
      present study demonstrated for the first time that other than white blood cell 
      count, eGFR was an independent correlate of serum levels of MCP-1 in a Japanese 
      general population. Elevated MCP-1 levels may partly explain the increased risk 
      of CVD in CKD patients.
CI  - (c) 2011 Wiley Periodicals, Inc.
FAU - Fukami, Ako
AU  - Fukami A
AD  - Department of Internal Medicine, Division of Cardio-Vascular Medicine, Kurume 
      University School of Medicine, Fukuoka, Japan.
FAU - Yamagishi, Sho-ichi
AU  - Yamagishi S
FAU - Adachi, Hisashi
AU  - Adachi H
FAU - Matsui, Takanori
AU  - Matsui T
FAU - Yoshikawa, Kuniko
AU  - Yoshikawa K
FAU - Ogata, Kinuka
AU  - Ogata K
FAU - Kasahara, Akiko
AU  - Kasahara A
FAU - Tsukagawa, Eri
AU  - Tsukagawa E
FAU - Yokoi, Kanako
AU  - Yokoi K
FAU - Imaizumi, Tsutomu
AU  - Imaizumi T
LA  - eng
PT  - Journal Article
DEP - 20110217
PL  - United States
TA  - Clin Cardiol
JT  - Clinical cardiology
JID - 7903272
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Atherosclerosis/blood
MH  - Chemokine CCL2/*blood
MH  - Epidemiologic Studies
MH  - Female
MH  - *Glomerular Filtration Rate
MH  - Humans
MH  - Japan/epidemiology
MH  - Kidney Failure, Chronic/blood
MH  - *Leukocyte Count
MH  - Male
MH  - Middle Aged
MH  - Sex Factors
MH  - Statistics as Topic
PMC - PMC6652339
EDAT- 2011/02/22 06:00
MHDA- 2011/07/16 06:00
PMCR- 2011/02/17
CRDT- 2011/02/22 06:00
PHST- 2010/07/15 00:00 [received]
PHST- 2010/07/30 00:00 [accepted]
PHST- 2011/02/22 06:00 [entrez]
PHST- 2011/02/22 06:00 [pubmed]
PHST- 2011/07/16 06:00 [medline]
PHST- 2011/02/17 00:00 [pmc-release]
AID - CLC20834 [pii]
AID - 10.1002/clc.20834 [doi]
PST - ppublish
SO  - Clin Cardiol. 2011 Mar;34(3):189-94. doi: 10.1002/clc.20834. Epub 2011 Feb 17.