PMID- 21337908
OWN - NLM
STAT- MEDLINE
DCOM- 20110725
LR  - 20161021
IS  - 0125-877X (Print)
IS  - 0125-877X (Linking)
VI  - 28
IP  - 4
DP  - 2010 Dec
TI  - Factors for high-risk asthma in Taiwanese children.
PG  - 250-5
AB  - BACKGROUND: Asthma is one of the major causes of death in otherwise healthy young 
      individuals. However, many of these deaths may have been prevented by more 
      aggressive treatment. To determine factors correlated with a high risk of death 
      in Taiwanese children with atopic asthma. METHODS: Taiwanese children aged 5-18 
      years, diagnosed with atopic asthma were enrolled in the study. Atopic asthma was 
      diagnosed and immunoglobulin E (IgE) specific to antigens from any 1 of 8 
      allergens was measured (i.e. Dermatophagoides pteronyssinus, Dermatophagoides 
      farinae, cat and dog dander, cockroach, egg white, milk and fish). High-risk 
      asthma was defined as asthma requiring admission to a hospital or a visit to an 
      emergency department. The study tried to determine the association of high-risk 
      asthma with allergy-related parameters (e.g. asthma severity, asthma score, total 
      serum IgE levels, serum levels of allergen-specific IgE, eosinophil count) and 
      pulmonary function in Taiwanese children. RESULTS: One thousand one hundred and 
      twenty-two Taiwanese children were evaluated. Those with higher asthma severity, 
      asthma symptom score, serum levels of IgE specific to D. pteronyssinus and D. 
      farinae, higher total serum IgE levels, and lower FEF25-75% (forced expiratory 
      flow, 25-75%) values were considered to be members of the high-risk asthma group. 
      CONCLUSIONS: The characterization of risk factors has enabled us to identify 
      high-risk asthma in Taiwanese children, which will facilitate the treatment of 
      these children in the future.
FAU - Cheng, Chieh-Han
AU  - Cheng CH
AD  - Division of Allergy, Immunology, Rheumatology Disease, Department of Pediatrics, 
      Mackay Memorial Hospital, Taipei, Taiwan.
FAU - Shyur, Shyh-Dar
AU  - Shyur SD
FAU - Huang, Li-Hsin
AU  - Huang LH
FAU - Kao, Yu-Hsuan
AU  - Kao YH
FAU - Lei, Wei-Te
AU  - Lei WT
FAU - Lo, Chia-Yi
AU  - Lo CY
FAU - Kuo-Hsi, Lee
AU  - Kuo-Hsi L
FAU - Chen, Chen-Kuan
AU  - Chen CK
FAU - Liu, Ling-Chun
AU  - Liu LC
LA  - eng
PT  - Journal Article
PL  - Thailand
TA  - Asian Pac J Allergy Immunol
JT  - Asian Pacific journal of allergy and immunology
JID - 8402034
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Allergens/*immunology
MH  - Animals
MH  - Asthma/blood/*epidemiology/*immunology/physiopathology
MH  - Child
MH  - Child, Preschool
MH  - Disease Progression
MH  - Eosinophils/*immunology
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Male
MH  - Respiratory Function Tests
MH  - Risk Factors
MH  - Taiwan
EDAT- 2011/02/23 06:00
MHDA- 2011/07/26 06:00
CRDT- 2011/02/23 06:00
PHST- 2011/02/23 06:00 [entrez]
PHST- 2011/02/23 06:00 [pubmed]
PHST- 2011/07/26 06:00 [medline]
PST - ppublish
SO  - Asian Pac J Allergy Immunol. 2010 Dec;28(4):250-5.