PMID- 21338694
OWN - NLM
STAT- MEDLINE
DCOM- 20110729
LR  - 20110912
IS  - 1095-9572 (Electronic)
IS  - 1053-8119 (Linking)
VI  - 56
IP  - 1
DP  - 2011 May 1
TI  - Magnetisation transfer ratio in optic neuritis is associated with axonal loss, 
      but not with demyelination.
PG  - 21-6
LID - 10.1016/j.neuroimage.2011.02.041 [doi]
AB  - BACKGROUND: Pathophysiological basis of Magnetisation Transfer Ratio (MTR) 
      reduction in multiple sclerosis still remains a matter of controversy. Optic 
      nerve represents an ideal model to study the consequences of axonal loss and 
      demyelination on MTR since effects of disease on the optic nerve are clinically 
      apparent and potentially quantifiable by objective means. By measuring the 
      latency of multifocal visual evoked potentials (mfVEP) (measure of optic nerve 
      conduction) and Retinal Nerve Fiber Layer (RNFL) thickness (measure of axonal 
      damage) we investigated the effect of neurodegeneration and demyelination on MTR 
      after an episode of optic neuritis (ON). METHODS: 23 patients with a single 
      unilateral episode of ON and 10 healthy volunteers were enrolled. Orbital MRI 
      including MTR protocol, Optical Coherence Tomography and Multifocal VEP were 
      performed at post-acute stage of ON. RESULTS: Average MTR of affected eye was 
      significantly reduced as compared to the fellow eye and normal controls. There 
      was a highly significant correlation between MTR and measures of axonal loss 
      (RNFL thickness and mfVEP amplitude), which was independent on the level of 
      demyelination. While latency delay also correlated significantly with MTR, 
      correlation became non-significant when adjusted for the degree of axonal loss. 
      There was a significant reduction of MTR in a group of patients with extensive 
      axonal damage, while MTR remained normal in a group of patients with extensive 
      demyelination, but little or no axonal loss. CONCLUSION: Results of this study 
      indicate that reduction of optic nerve MTR after an episode of ON has a strong 
      association with the degree of axonal damage, but not with demyelination.
CI  - Crown Copyright (c) 2011. Published by Elsevier Inc. All rights reserved.
FAU - Klistorner, A
AU  - Klistorner A
AD  - Department of Ophthalmology, Save Sight Institute, University of Sydney, Sydney, 
      Australia. sasha@eye.usyd.edu.au
FAU - Chaganti, J
AU  - Chaganti J
FAU - Garrick, R
AU  - Garrick R
FAU - Moffat, K
AU  - Moffat K
FAU - Yiannikas, C
AU  - Yiannikas C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110219
PL  - United States
TA  - Neuroimage
JT  - NeuroImage
JID - 9215515
SB  - IM
EIN - Neuroimage. 2011 Jun 15;56(4):2375
MH  - Adult
MH  - Demyelinating Diseases/*pathology/physiopathology
MH  - Evoked Potentials, Visual/physiology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Nerve Degeneration/*pathology/physiopathology
MH  - Optic Nerve/pathology/physiopathology
MH  - Optic Neuritis/*pathology/physiopathology
EDAT- 2011/02/23 06:00
MHDA- 2011/07/30 06:00
CRDT- 2011/02/23 06:00
PHST- 2010/09/18 00:00 [received]
PHST- 2011/02/08 00:00 [revised]
PHST- 2011/02/14 00:00 [accepted]
PHST- 2011/02/23 06:00 [entrez]
PHST- 2011/02/23 06:00 [pubmed]
PHST- 2011/07/30 06:00 [medline]
AID - S1053-8119(11)00197-2 [pii]
AID - 10.1016/j.neuroimage.2011.02.041 [doi]
PST - ppublish
SO  - Neuroimage. 2011 May 1;56(1):21-6. doi: 10.1016/j.neuroimage.2011.02.041. Epub 
      2011 Feb 19.