PMID- 21339088
OWN - NLM
STAT- MEDLINE
DCOM- 20110705
LR  - 20131121
IS  - 1579-2021 (Electronic)
IS  - 1575-0922 (Linking)
VI  - 58
IP  - 2
DP  - 2011 Feb
TI  - [About a case of multiple endocrine neoplasia type 1. Review of some clinical 
      manifestations and treatment controversies].
PG  - 84-9
LID - 10.1016/j.endonu.2010.10.011 [doi]
AB  - The rare hereditary syndrome, multiple endocrine neoplasia type1 (MEN-1), is 
      known to predispose affected individuals to endocrine neoplasms in a variety of 
      tissues such as the parathyroid glands, the pituitary gland and the 
      gastrointestinal tract. We describe the case of a man with 
      traditionally-described manifestations (hyperparathyroidism and gastrinoma) and 
      with other tumoral lesions arising from endocrine cells (insulinoma, gastric 
      carcinoid, adrenal adenoma and pancreatic non-functioning neuroendocrine tumors) 
      and non-endocrine cells (lipoma and collagenoma). Frequent recurrences in 
      susceptible tissues that are not totally removed (as occurs in 
      hyperparathyroidism and duodenal gastrinoma) and their unknown clinical 
      significance have aroused current controversies in the therapeutic management of 
      these entities, which is briefly reviewed.
CI  - Copyright (c) 2010 SEEN. Published by Elsevier Espana. All rights reserved.
FAU - Familiar, Cristina
AU  - Familiar C
AD  - Servicio de Endocrinologia, Hospital de Mostoles, Mostoles, Madrid, Espana. 
      crisfami@terra.es
FAU - Anton, Teresa
AU  - Anton T
FAU - Moraga, Inmaculada
AU  - Moraga I
FAU - Ramos, Araceli
AU  - Ramos A
FAU - Marco, Angel
AU  - Marco A
LA  - spa
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - A proposito de un caso de neoplasia endocrina multiple tipo 1. Revision de 
      algunas manifestaciones clinicas y controversias en el tratamiento.
DEP - 20110220
PL  - Spain
TA  - Endocrinol Nutr
JT  - Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y 
      Nutricion
JID - 100886482
RN  - KG60484QX9 (Omeprazole)
RN  - RWM8CCW8GP (Octreotide)
SB  - IM
MH  - Adenoma/genetics
MH  - Adrenal Gland Neoplasms/genetics
MH  - Adult
MH  - Carcinoid Tumor/genetics
MH  - Combined Modality Therapy
MH  - Duodenal Neoplasms/drug therapy/genetics/surgery
MH  - Fibroma/genetics
MH  - Gastrinoma/drug therapy/genetics/surgery
MH  - Humans
MH  - Hyperparathyroidism/drug therapy/genetics
MH  - Insulinoma/genetics
MH  - Lipoma/genetics
MH  - Lymphatic Metastasis
MH  - Male
MH  - Multiple Endocrine Neoplasia Type 1/drug therapy/*pathology
MH  - Neuroendocrine Tumors/drug therapy/genetics
MH  - Octreotide/therapeutic use
MH  - Omeprazole/therapeutic use
MH  - Pancreatic Neoplasms/genetics/surgery
MH  - Skin Neoplasms/genetics
MH  - Stomach Neoplasms/genetics
EDAT- 2011/02/23 06:00
MHDA- 2011/07/06 06:00
CRDT- 2011/02/23 06:00
PHST- 2010/08/23 00:00 [received]
PHST- 2010/10/06 00:00 [revised]
PHST- 2010/10/08 00:00 [accepted]
PHST- 2011/02/23 06:00 [entrez]
PHST- 2011/02/23 06:00 [pubmed]
PHST- 2011/07/06 06:00 [medline]
AID - S1575-0922(10)00307-4 [pii]
AID - 10.1016/j.endonu.2010.10.011 [doi]
PST - ppublish
SO  - Endocrinol Nutr. 2011 Feb;58(2):84-9. doi: 10.1016/j.endonu.2010.10.011. Epub 
      2011 Feb 20.