PMID- 21339227
OWN - NLM
STAT- MEDLINE
DCOM- 20110325
LR  - 20110222
IS  - 1468-2060 (Electronic)
IS  - 0003-4967 (Linking)
VI  - 70 Suppl 1
DP  - 2011 Mar
TI  - miR-124a as a key regulator of proliferation and MCP-1 secretion in synoviocytes 
      from patients with rheumatoid arthritis.
PG  - i88-91
LID - 10.1136/ard.2010.138669 [doi]
AB  - MicroRNAs (miRNA) are a class of small endogenous non-coding RNAs that influence 
      the stability and translation of messenger RNA. Synoviocytes from patients with 
      rheumatoid arthritis (RA) were analysed for their miRNA expression profile, and 
      it was found that miR-124a levels significantly decreased in RA synoviocytes as 
      compared with osteoarthritis synoviocytes. Transfection of miR-124a into RA 
      synoviocytes significantly suppressed their proliferation and arrested the cell 
      cycle at the G1 phase. miR-124a directly binds to the 3'-untranslated region of 
      cyclin-dependent kinase 2 (CDK-2) and monocyte chemoattractant protein 1 (MCP-1) 
      mRNA, and the induction of miR-124a in RA synoviocytes significantly suppressed 
      the production of the CDK-2 and MCP-1 proteins. It is proposed that miR-124a is a 
      key miRNA in the post-transcriptional regulatory mechanisms of RA synoviocytes, 
      and has a therapeutic potential.
FAU - Kawano, Seiji
AU  - Kawano S
AD  - Department of Clinical Laboratory, Kobe University Hospital, 7-5-2 Kusunoki-cho, 
      Chuo-ku, Kobe, Hyogo 650-0017, Japan. sjkawano@med.kobe-u.ac.jp
FAU - Nakamachi, Yuji
AU  - Nakamachi Y
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Ann Rheum Dis
JT  - Annals of the rheumatic diseases
JID - 0372355
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (MIRN124 microRNA, human)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Arthritis, Rheumatoid/genetics/immunology/*metabolism/pathology
MH  - Cell Proliferation
MH  - Chemokine CCL2/*metabolism
MH  - Humans
MH  - MicroRNAs/immunology/*physiology
MH  - Synovial Membrane/*metabolism/pathology
EDAT- 2011/02/26 06:00
MHDA- 2011/03/26 06:00
CRDT- 2011/02/23 06:00
PHST- 2011/02/23 06:00 [entrez]
PHST- 2011/02/26 06:00 [pubmed]
PHST- 2011/03/26 06:00 [medline]
AID - 70/Suppl_1/i88 [pii]
AID - 10.1136/ard.2010.138669 [doi]
PST - ppublish
SO  - Ann Rheum Dis. 2011 Mar;70 Suppl 1:i88-91. doi: 10.1136/ard.2010.138669.