PMID- 21339405
OWN - NLM
STAT- MEDLINE
DCOM- 20110419
LR  - 20161125
IS  - 1538-361X (Electronic)
IS  - 0886-4470 (Linking)
VI  - 137
IP  - 2
DP  - 2011 Feb
TI  - A higher CD105-assessed microvessel density and worse prognosis in elderly 
      patients with laryngeal carcinoma.
PG  - 175-80
LID - 10.1001/archoto.2010.244 [doi]
AB  - OBJECTIVES: To ascertain the prognostic role of endoglin (CD105)-assessed 
      microvessel density (MVD) in patients older than 65 years with laryngeal squamous 
      cell carcinoma (LSCC), and whether this MVD differed in the elderly patients from 
      younger adult controls. DESIGN: Retrospective clinicopathologic investigation. 
      SETTING: Academic tertiary referral center. PATIENTS: Fifty-seven consecutive 
      elderly patients with LSCC and 19 younger adult controls. MAIN OUTCOME MEASURE: 
      Image analysis of immunohistochemical reactions. RESULTS: In LSCCs in elderly 
      patients, N+ stage correlated with a shorter disease-free survival (DFS) (P < 
      .001). A higher CD105-assessed MVD was associated with disease recurrence (P = 
      .006). The DFS was shorter in elderly patients whose CD105 expression was greater 
      than 9.6% than in patients whose CD105 expression was 9.6% or less (P = .001). 
      Among the elderly patients with tumors staged as N0, a higher CD105-assessed MVD 
      correlated with disease recurrence (P = .006) and a shorter DFS (P = .001). 
      CD105-assessed MVD in LSCC occurring in elderly patients did not differ from the 
      situation observed in younger adult controls (P = .74). CONCLUSIONS: In LSCC 
      occurring in elderly patients, CD105-assessed MVD may be a useful N-stage 
      independent, angiogenic prognostic marker for pinpointing: (1) patients at higher 
      risk of disease recurrence; and (2) patients with N0 tumors at higher risk of 
      early recurrence, who may benefit from more aggressive therapy.
FAU - Marioni, Gino
AU  - Marioni G
AD  - Department of Medical and Surgical Specialties, Otolaryngology Section, 
      University of Padova, Via Giustiniani 2, 35128 Padova, Italy. 
      gino.marioni@unipd.it
FAU - Staffieri, Alberto
AU  - Staffieri A
FAU - Manzato, Enzo
AU  - Manzato E
FAU - Ralli, Giovanni
AU  - Ralli G
FAU - Lionello, Marco
AU  - Lionello M
FAU - Giacomelli, Luciano
AU  - Giacomelli L
FAU - Prosenikliev, Vlatko
AU  - Prosenikliev V
FAU - Marchese-Ragona, Rosario
AU  - Marchese-Ragona R
FAU - Busnardo, Alessandra
AU  - Busnardo A
FAU - Bolzetta, Francesco
AU  - Bolzetta F
FAU - Blandamura, Stella
AU  - Blandamura S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Arch Otolaryngol Head Neck Surg
JT  - Archives of otolaryngology--head & neck surgery
JID - 8603209
RN  - 0 (Antigens, CD)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (ENG protein, human)
RN  - 0 (Endoglin)
RN  - 0 (Receptors, Cell Surface)
SB  - IM
MH  - Aged
MH  - Antigens, CD/*analysis
MH  - Biomarkers, Tumor/analysis
MH  - Carcinoma, Squamous Cell/*blood supply/mortality/pathology/therapy
MH  - Case-Control Studies
MH  - Endoglin
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Laryngeal Neoplasms/*blood supply/mortality/pathology/therapy
MH  - Male
MH  - Microvessels/*pathology
MH  - Neoplasm Recurrence, Local/*pathology
MH  - Neovascularization, Pathologic/pathology
MH  - Prognosis
MH  - Receptors, Cell Surface/*analysis
MH  - Retrospective Studies
EDAT- 2011/02/23 06:00
MHDA- 2011/04/20 06:00
CRDT- 2011/02/23 06:00
PHST- 2011/02/23 06:00 [entrez]
PHST- 2011/02/23 06:00 [pubmed]
PHST- 2011/04/20 06:00 [medline]
AID - 137/2/175 [pii]
AID - 10.1001/archoto.2010.244 [doi]
PST - ppublish
SO  - Arch Otolaryngol Head Neck Surg. 2011 Feb;137(2):175-80. doi: 
      10.1001/archoto.2010.244.