PMID- 21339450
OWN - NLM
STAT- MEDLINE
DCOM- 20110404
LR  - 20110222
IS  - 1538-3652 (Electronic)
IS  - 0003-987X (Linking)
VI  - 147
IP  - 2
DP  - 2011 Feb
TI  - Two cases of multiple spitz nevi: correlating clinical, histologic, and 
      fluorescence in situ hybridization findings.
PG  - 227-31
LID - 10.1001/archdermatol.2010.439 [doi]
AB  - BACKGROUND: The occurrence of multiple Spitz nevi is rare, especially the 
      disseminated variant. Multiple Spitz nevi may be confused with, and must be 
      differentiated from, primary spitzoid melanoma and cutaneous melanoma metastases. 
      Over the past decade, fluorescence in situ hybridization (FISH) has emerged as a 
      tool for studying melanocytic neoplasms, helping to differentiate between 
      melanoma and benign melanocytic nevi. We describe 2 cases of patients with 
      multiple Spitz nevi and their FISH results. OBSERVATIONS: One case of 
      disseminated Spitz nevi, in a 17-year-old female, showed balanced tetraploidy 
      using FISH, while the other case, in a 51-year-old female with multiple Spitz 
      nevi, showed normal diploid cells without significant gains or losses in 
      chromosomes 6 or 11. CONCLUSIONS: Patients may present with multiple, even 
      disseminated, Spitz nevi. This phenotype should not be confused with melanoma 
      and/or cutaneous metastasis. The use of FISH studies in context with careful 
      correlation of clinical features and dermoscopic and histologic findings can 
      assist in the diagnostic workup.
CI  - (c)2011 American Medical Association. All rights reserved.
FAU - Boone, Susan L
AU  - Boone SL
AD  - Department of Dermatology, Northwestern University Feinberg School of Medicine, 
      Chicago, IL 60611, USA.
FAU - Busam, Klaus J
AU  - Busam KJ
FAU - Marghoob, Ashfaq A
AU  - Marghoob AA
FAU - Fang, Yuqiang
AU  - Fang Y
FAU - Guitart, Joan
AU  - Guitart J
FAU - Martini, Mary
AU  - Martini M
FAU - Gerami, Pedram
AU  - Gerami P
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Arch Dermatol
JT  - Archives of dermatology
JID - 0372433
SB  - IM
CIN - Arch Dermatol. 2011 Feb;147(2):232-3. PMID: 21339451
MH  - Adolescent
MH  - Chromosome Aberrations
MH  - Diagnosis, Differential
MH  - Diploidy
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Middle Aged
MH  - Nevus, Epithelioid and Spindle Cell/genetics/*pathology
MH  - Skin Neoplasms/genetics/*pathology
MH  - Tetraploidy
EDAT- 2011/02/23 06:00
MHDA- 2011/04/05 06:00
CRDT- 2011/02/23 06:00
PHST- 2011/02/23 06:00 [entrez]
PHST- 2011/02/23 06:00 [pubmed]
PHST- 2011/04/05 06:00 [medline]
AID - 147/2/227 [pii]
AID - 10.1001/archdermatol.2010.439 [doi]
PST - ppublish
SO  - Arch Dermatol. 2011 Feb;147(2):227-31. doi: 10.1001/archdermatol.2010.439.