PMID- 21340774
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20110222
IS  - 1543-1894 (Print)
IS  - 1543-1894 (Linking)
VI  - 39
DP  - 2001
TI  - Cytogenetics of ovarian cancer technical overview.
PG  - 207-13
LID - 10.1385/1-59259-071-3:207 [doi]
AB  - Cytogenetics in ovarian cancer has been restricted to conventional cytogenetic 
      analysis of G-banded metaphase chromosomes up to the early 1980s. The detection 
      of cytogenetic changes in solid tumors was relatively limited, as cytogenetic 
      preparations from solid tumor tissue often have a low yield of metaphases with 
      poor quality chromosomes (1). Following the advent of the fluorescence in situ 
      hybridization (FISH) technique (2,3) it became possible to obtain huge amounts of 
      additional cytogenetic information from the material available. This fact is 
      demonstrated very clearly by the following comparison: Mitelman summarizes in the 
      4th edition of Catalog of Chromosome Aberrations in Cancer only 185 cases of 
      ovarian cancer, which were characterized by conventional cytogenetic analysis 
      between about 1970 to 1991 (4). On the other hand, 135 cases of ovarian cancer 
      have been analyzed by means of comparative genomic hybridization (CGH) in the 
      shorter time period 1995 to 1997 (5-8).
FAU - Liehr, T
AU  - Liehr T
AD  - Institut fur Humangenetik, Jena, Germany.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Methods Mol Med
JT  - Methods in molecular medicine
JID - 101123138
EDAT- 2001/01/01 00:00
MHDA- 2001/01/01 00:01
CRDT- 2011/02/23 06:00
PHST- 2011/02/23 06:00 [entrez]
PHST- 2001/01/01 00:00 [pubmed]
PHST- 2001/01/01 00:01 [medline]
AID - 10.1385/1-59259-071-3:207 [doi]
PST - ppublish
SO  - Methods Mol Med. 2001;39:207-13. doi: 10.1385/1-59259-071-3:207.