PMID- 21342224
OWN - NLM
STAT- MEDLINE
DCOM- 20110628
LR  - 20161125
IS  - 1346-8138 (Electronic)
IS  - 0385-2407 (Linking)
VI  - 38
IP  - 3
DP  - 2011 Mar
TI  - Hypersensitivity syndrome due to trichloroethylene exposure: a severe generalized 
      skin reaction resembling drug-induced hypersensitivity syndrome.
PG  - 229-35
LID - 10.1111/j.1346-8138.2010.01155.x [doi]
AB  - The number of patients suffering from trichloroethylene (TCE)-related severe skin 
      disorders with liver dysfunction has been increasing in developing countries in 
      Asia, especially since the mid-1990s. In Japan, five cases of this disease have 
      been reported, but none since the 1990s. However, two additional cases were 
      recently observed in Tokyo. The published work and our investigation indicated 
      that oxidative metabolites of TCE, which might include 
      trichloroacetylated-protein adducts, could induce a generalized skin eruption. 
      Furthermore, human leukocyte antigen (HLA)-B*1301 and HLA-B*44 were identified as 
      markers of individual susceptibility to TCE-induced hypersensitivity syndrome 
      (HS). Moreover, polymorphism of aldehyde dehydrogenase (ALDH), the major enzyme 
      in TCE metabolism, appeared to be associated with TCE-induced HS. Interestingly, 
      this disorder is quite similar to drug-induced hypersensitivity syndrome (DIHS), 
      also referred to as drug rash with eosinophilia and systemic symptoms (DRESS), 
      from the perspective of the onset of the reaction after exposure to TCE/drugs, 
      clinical manifestations, blood examination and period of virus reactivation. This 
      article reviews the similarity between TCE-related HS and DIHS/DRESS.
CI  - (c) 2011 Japanese Dermatological Association.
FAU - Watanabe, Hideaki
AU  - Watanabe H
AD  - Department of Dermatology, Showa University School of Medicine, Tokyo, Japan. 
      hwatanabe@med.showa-u.ac.jp
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - J Dermatol
JT  - The Journal of dermatology
JID - 7600545
RN  - 290YE8AR51 (Trichloroethylene)
SB  - IM
MH  - Animals
MH  - Chemical and Drug Induced Liver Injury/diagnosis/etiology
MH  - Drug Eruptions/diagnosis/etiology
MH  - Drug Hypersensitivity/*diagnosis/*etiology
MH  - Environmental Exposure/adverse effects
MH  - Eosinophilia
MH  - Herpesvirus 6, Human/physiology
MH  - Humans
MH  - Syndrome
MH  - Trichloroethylene/metabolism/*toxicity
MH  - Virus Activation
EDAT- 2011/02/24 06:00
MHDA- 2011/06/29 06:00
CRDT- 2011/02/24 06:00
PHST- 2011/02/24 06:00 [entrez]
PHST- 2011/02/24 06:00 [pubmed]
PHST- 2011/06/29 06:00 [medline]
AID - 10.1111/j.1346-8138.2010.01155.x [doi]
PST - ppublish
SO  - J Dermatol. 2011 Mar;38(3):229-35. doi: 10.1111/j.1346-8138.2010.01155.x.