PMID- 21342273
OWN - NLM
STAT- MEDLINE
DCOM- 20110822
LR  - 20110412
IS  - 1600-0714 (Electronic)
IS  - 0904-2512 (Linking)
VI  - 40
IP  - 5
DP  - 2011 May
TI  - Distinct expression of perforin and granzyme B in lip and oral cavity squamous 
      cell carcinoma.
PG  - 380-4
LID - 10.1111/j.1600-0714.2011.01014.x [doi]
AB  - BACKGROUND: Perforin and granzyme B (GB) are the main constituents of cytotoxic 
      T-lymphocyte granules, and they have important roles in preventing the initiation 
      and progression of cancer. METHODS: The aim of this study was to compare the 
      expression of CD8(+) /perforin(+) double-staining and GB(+) cells, by 
      immunohistochemistry, in primary oral cavity squamous cell carcinoma (OCSCC), lip 
      squamous cell carcinoma (LSCC), non-dysplastic leukoplakia (LK), dysplastic LK, 
      actinic cheilitis (AC), oral lichen planus (LP) and normal oral mucosa. RESULTS: 
      Our results showed a higher expression of CD8(+) /perforin(+) and GB(+) cells in 
      LSCC when compared with the samples of OCSCC, non-dysplastic and dysplastic LK, 
      AC, oral LP and normal oral mucosa. In addition, increased CD8(+) /perforin(+) 
      and GB(+) cell numbers were observed in all pre-malignant lesions (non-dysplastic 
      LK, dysplastic LK, AC) when compared with the control. CONCLUSIONS: Perforin and 
      GB proteins may contribute to antitumoural immunity, leading to the direct 
      killing of tumour cells; however, it seems to occur more effectively in LSCC than 
      OCSCC.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Costa, Nadia Lago
AU  - Costa NL
AD  - Department of Stomatology (Oral Pathology), Dental School, Federal University of 
      Goias, Goiania, Brazil.
FAU - Goncalves, Andreia Souza
AU  - Goncalves AS
FAU - Souza-Lima, Nathalia Caroline
AU  - Souza-Lima NC
FAU - Jaime-Paiva, Luis Gustavo
AU  - Jaime-Paiva LG
FAU - Junqueira-Kipnis, Ana Paula
AU  - Junqueira-Kipnis AP
FAU - Silva, Tarcilia Aparecida
AU  - Silva TA
FAU - Mendonca, Elismauro Francisco
AU  - Mendonca EF
FAU - Batista, Aline Carvalho
AU  - Batista AC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110222
PL  - Denmark
TA  - J Oral Pathol Med
JT  - Journal of oral pathology & medicine : official publication of the International 
      Association of Oral Pathologists and the American Academy of Oral Pathology
JID - 8911934
RN  - 126465-35-8 (Perforin)
RN  - EC 3.4.21.- (Granzymes)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Apoptosis/physiology
MH  - Carcinoma, Squamous Cell/immunology/*metabolism
MH  - Case-Control Studies
MH  - Cheilitis/metabolism
MH  - Female
MH  - Granzymes/*biosynthesis
MH  - Humans
MH  - Leukoplakia, Oral/metabolism
MH  - Lichen Planus, Oral/metabolism
MH  - Lip Neoplasms/immunology/metabolism
MH  - Lymphocyte Count
MH  - Male
MH  - Middle Aged
MH  - Mouth Floor/immunology/metabolism
MH  - Mouth Mucosa/metabolism
MH  - Mouth Neoplasms/immunology/*metabolism
MH  - Perforin/*biosynthesis
MH  - Statistics, Nonparametric
MH  - T-Lymphocytes, Cytotoxic/chemistry/metabolism
EDAT- 2011/02/24 06:00
MHDA- 2011/08/23 06:00
CRDT- 2011/02/24 06:00
PHST- 2011/02/24 06:00 [entrez]
PHST- 2011/02/24 06:00 [pubmed]
PHST- 2011/08/23 06:00 [medline]
AID - 10.1111/j.1600-0714.2011.01014.x [doi]
PST - ppublish
SO  - J Oral Pathol Med. 2011 May;40(5):380-4. doi: 10.1111/j.1600-0714.2011.01014.x. 
      Epub 2011 Feb 22.