PMID- 21343212
OWN - NLM
STAT- MEDLINE
DCOM- 20121105
LR  - 20131121
IS  - 1530-8022 (Electronic)
IS  - 0885-3282 (Linking)
VI  - 27
IP  - 1
DP  - 2012 Jul
TI  - Preparation of combined beta-TCP/alpha-CSH artificial bone graft and its performance in 
      a spinal fusion model.
PG  - 37-45
LID - 10.1177/0885328210391919 [doi]
AB  - To evaluate alpha-calcium sulfate hemihydrate (alpha-CSH)/beta-tricalcium phosphate (beta-TCP) 
      combined artificial bone graft (COB) in an animal model of posterolateral spinal 
      fusion, alpha-CSH and beta-TCP were combined in a 3 : 7 weight ratio. A rabbit model of 
      posterolateral spinal fusion was produced (N = 36); one side was implanted with 
      the COB, and the other with local autogenous bone. Rabbits were killed on the 
      4th, 8th, or 12th week after surgery and fusion, COB degradation, mineralization, 
      and new bone formation were evaluated. Scanning electron microscopy revealed that 
      the COB retained the porous spatial structure of beta-TCP and alpha-CSH crystals were 
      adhered to the surface and pores of beta-TCP. At the 12th week after surgery, the 
      fusion rate was 75.0% on the 12th week after the operation, which was higher than 
      the fusion rate of 54.4% the autogenous bone side (p = 0.073). Bone volume 
      fraction of the COB was 0.49 +/- 0.08 for the 4th week and 0.16 +/- 0.05 for the 12th 
      week after surgery. The mineralization rate of the new bone was greater on the 
      side implanted with autogenous bone than on the side implanted with COB at all 
      the three time points after surgery. At each time point after surgery, the 
      difference in mineralization rate between the autogenous bone side and the COB 
      side was statistically significant (p < 0.001); alpha-CSH/beta-TCP in a 3 : 7 weight 
      ratio was as effective as local autogenous bone in producing spinal fusion in a 
      rabbit model. Used in this ratio, the speed of material degradation and new bone 
      formation are relatively equivalent, and the rate of new bone mineralization is 
      similar to that of autogenous bone graft.
FAU - Mao, Keya
AU  - Mao K
AD  - Department of Orthopedics, General Hospital of People's Liberation Army, Beijing, 
      People's Republic of China. maokeya@sina.com
FAU - Cui, Fuzai
AU  - Cui F
FAU - Li, Jiangtao
AU  - Li J
FAU - Hao, Libo
AU  - Hao L
FAU - Tang, Peifu
AU  - Tang P
FAU - Wang, Zheng
AU  - Wang Z
FAU - Wen, Ning
AU  - Wen N
FAU - Liang, Maohua
AU  - Liang M
FAU - Wang, Jifang
AU  - Wang J
FAU - Wang, Yan
AU  - Wang Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110222
PL  - England
TA  - J Biomater Appl
JT  - Journal of biomaterials applications
JID - 8813912
RN  - 0 (Bone Substitutes)
RN  - 0 (Calcium Phosphates)
RN  - 0 (beta-tricalcium phosphate)
RN  - WAT0DDB505 (Calcium Sulfate)
SB  - IM
MH  - Animals
MH  - *Bone Substitutes
MH  - Calcium Phosphates/*chemistry
MH  - Calcium Sulfate/*chemistry
MH  - Microscopy, Electron, Scanning
MH  - *Models, Animal
MH  - Rabbits
MH  - Rats
MH  - *Spinal Fusion
MH  - Tomography, X-Ray Computed
MH  - X-Ray Diffraction
EDAT- 2011/02/24 06:00
MHDA- 2012/11/06 06:00
CRDT- 2011/02/24 06:00
PHST- 2011/02/24 06:00 [entrez]
PHST- 2011/02/24 06:00 [pubmed]
PHST- 2012/11/06 06:00 [medline]
AID - 0885328210391919 [pii]
AID - 10.1177/0885328210391919 [doi]
PST - ppublish
SO  - J Biomater Appl. 2012 Jul;27(1):37-45. doi: 10.1177/0885328210391919. Epub 2011 
      Feb 22.