PMID- 21343336
OWN - NLM
STAT- MEDLINE
DCOM- 20110620
LR  - 20171116
IS  - 1479-683X (Electronic)
IS  - 0804-4643 (Linking)
VI  - 164
IP  - 5
DP  - 2011 May
TI  - Upregulation of thyroid transcription factor-1 and human leukocyte antigen class 
      I in Hashimoto's disease providing a clinical evidence for possible triggering 
      autoimmune reaction.
PG  - 795-800
LID - 10.1530/EJE-10-0960 [doi]
AB  - OBJECTIVE: An increase in the expression of autoantigens and their presenting 
      molecules human leukocyte antigen (HLA) class I has been demonstrated to be 
      responsible for autoimmune diseases. Thyroid transcription factor-1 (TTF-1 or 
      NKX2-1) synchronously upregulates both HLA class I and thyroid-specific 
      autoantigen, which may be involved in the pathological process of autoimmune 
      thyroiditis. In this study, the expressions and potential role of TTF-1 and HLA 
      class I in Hashimoto's disease (HT) were examined. PATIENTS: In this study, 22 
      resection specimens clinically and histopathologically confirmed to have 
      Hashimoto's disease and 30 normal thyroid specimens from adjacent tissues of 
      thyroid adenoma were used. MEASUREMENT: Western blot, real-time PCR, and 
      immunohistochemistry were performed to assay TTF-1 and HLA class I in the 
      thyrocytes of Hashimoto's disease as well as in the normal thyroid from adjacent 
      tissues of thyroid adenoma. RESULTS: The TTF-1 and HLA class I in Hashimoto's 
      disease were significantly higher than those in the controls. CONCLUSION: 
      Upregulation of TTF-1 and HLA class I in Hashimoto's disease provide a clinical 
      evidence for possible triggering of autoimmune reaction.
FAU - Huang, Huibin
AU  - Huang H
AD  - Second Affiliated Hospital of Fujian Medical University, Quanzhou, People's 
      Republic of China.
FAU - Li, Xisheng
AU  - Li X
FAU - Lin, Ling
AU  - Lin L
FAU - Shi, Yaxiong
AU  - Shi Y
FAU - Lin, Xiahong
AU  - Lin X
FAU - Li, Liangyi
AU  - Li L
FAU - Xu, Dongming
AU  - Xu D
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110222
PL  - England
TA  - Eur J Endocrinol
JT  - European journal of endocrinology
JID - 9423848
RN  - 0 (Autoantibodies)
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (NKX2-1 protein, human)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Thyroid Nuclear Factor 1)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Autoantibodies/biosynthesis
MH  - Female
MH  - HLA Antigens/*biosynthesis/immunology
MH  - Hashimoto Disease/*immunology/*metabolism/pathology
MH  - Histocompatibility Antigens Class I/*biosynthesis/immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nuclear Proteins/*biosynthesis/physiology
MH  - Thyroid Nuclear Factor 1
MH  - Transcription Factors/*biosynthesis/physiology
MH  - Up-Regulation/*immunology
EDAT- 2011/02/24 06:00
MHDA- 2011/06/21 06:00
CRDT- 2011/02/24 06:00
PHST- 2011/02/24 06:00 [entrez]
PHST- 2011/02/24 06:00 [pubmed]
PHST- 2011/06/21 06:00 [medline]
AID - EJE-10-0960 [pii]
AID - 10.1530/EJE-10-0960 [doi]
PST - ppublish
SO  - Eur J Endocrinol. 2011 May;164(5):795-800. doi: 10.1530/EJE-10-0960. Epub 2011 
      Feb 22.