PMID- 21343441
OWN - NLM
STAT- MEDLINE
DCOM- 20111004
LR  - 20211020
IS  - 1098-6596 (Electronic)
IS  - 0066-4804 (Print)
IS  - 0066-4804 (Linking)
VI  - 55
IP  - 5
DP  - 2011 May
TI  - Case report of a successful treatment of methicillin-resistant Staphylococcus 
      aureus (MRSA) bacteremia and MRSA/vancomycin-resistant Enterococcus faecium 
      cholecystitis by daptomycin.
PG  - 2458-9
LID - 10.1128/AAC.01774-10 [doi]
AB  - A 72-year-old man, receiving 8 mg daptomycin/kg body weight/day for 
      methicillin-resistant Staphylococcus aureus (MRSA) bacteremia, was diagnosed with 
      MRSA/vancomycin-resistant Enterococcus faecium (VRE) cholecystitis (daptomycin 
      MIC values, 1 and 2 mg/liter, respectively). After the fifth drug dose, the bile 
      concentration of daptomycin was 66 mg/liter 5 min after drug administration, with 
      the biliary concentration/MIC values higher than 30 for both bacterial strains. 
      Therefore, daptomycin achieved therapeutic levels in bile, hence suggesting a 
      role for the drug in the treatment of MRSA/VRE cholecystitis.
FAU - Tascini, Carlo
AU  - Tascini C
AD  - Infectious Diseases Unit, Santa Chiara University Hospital, and Division of 
      Pharmacology, Department of Internal Medicine, University of Pisa, Via Roma 55, 
      56126 Pisa, Italy.
FAU - Di Paolo, Antonello
AU  - Di Paolo A
FAU - Polillo, Marialuisa
AU  - Polillo M
FAU - Ferrari, Mauro
AU  - Ferrari M
FAU - Lambelet, Paola
AU  - Lambelet P
FAU - Danesi, Romano
AU  - Danesi R
FAU - Menichetti, Francesco
AU  - Menichetti F
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20110222
PL  - United States
TA  - Antimicrob Agents Chemother
JT  - Antimicrobial agents and chemotherapy
JID - 0315061
RN  - 0 (Anti-Bacterial Agents)
RN  - 6Q205EH1VU (Vancomycin)
RN  - NWQ5N31VKK (Daptomycin)
SB  - IM
MH  - Aged
MH  - Anti-Bacterial Agents/*therapeutic use
MH  - Bacteremia/*drug therapy/microbiology
MH  - Cholecystitis/*drug therapy/*microbiology
MH  - Daptomycin/*therapeutic use
MH  - Enterococcus faecium/drug effects/*pathogenicity
MH  - Humans
MH  - Male
MH  - Methicillin-Resistant Staphylococcus aureus/*drug effects/pathogenicity
MH  - Vancomycin/*therapeutic use
PMC - PMC3088188
EDAT- 2011/02/24 06:00
MHDA- 2011/10/05 06:00
PMCR- 2011/11/01
CRDT- 2011/02/24 06:00
PHST- 2011/02/24 06:00 [entrez]
PHST- 2011/02/24 06:00 [pubmed]
PHST- 2011/10/05 06:00 [medline]
PHST- 2011/11/01 00:00 [pmc-release]
AID - AAC.01774-10 [pii]
AID - 1774-10 [pii]
AID - 10.1128/AAC.01774-10 [doi]
PST - ppublish
SO  - Antimicrob Agents Chemother. 2011 May;55(5):2458-9. doi: 10.1128/AAC.01774-10. 
      Epub 2011 Feb 22.