PMID- 21345709
OWN - NLM
STAT- MEDLINE
DCOM- 20120322
LR  - 20220408
IS  - 1878-1780 (Electronic)
IS  - 1262-3636 (Linking)
VI  - 37
IP  - 4
DP  - 2011 Sep
TI  - Vitamin D and type 2 diabetes mellitus: where do we stand?
PG  - 265-72
LID - 10.1016/j.diabet.2011.01.001 [doi]
AB  - AIMS: In-vitro and observational studies have established a link between vitamin 
      D deficiency and different type 2 diabetes outcomes (insulin resistance, insulin 
      secretion, glucose intolerance). Although the number of randomized controlled 
      trials vs placebo is small, vitamin D (VTD) has been shown to prevent increases 
      in glucose concentration and insulin resistance, enhance insulin sensitivity and 
      reduce systolic blood pressure in type 2 diabetic patients. METHODS: In this 
      review, we have focused on the potential mechanisms that might explain the 
      association between VTD and type 2 diabetes mellitus (T2DM). We have also 
      evaluated the different epidemiological and observational studies on the topic, 
      as well as the various interventional studies. RESULTS: Although the in vitro 
      studies appear to be promising in explaining the link between VTD metabolism and 
      T2DM, the results of in vivo studies are conflicting. This could be related to 
      differences in their methodological approaches. CONCLUSION: Although more studies 
      are needed to confirm the role of VTD in the treatment of T2DM, there is 
      nevertheless enough evidence at this time to suggest a need to maintain 25-OH 
      vitamin D levels in T2DM patients around 30 ng/mL over the course of a year.
CI  - Copyright (c) 2011 Elsevier Masson SAS. All rights reserved.
FAU - Cavalier, E
AU  - Cavalier E
AD  - Department of Clinical Chemistry, University of Liege, CHU Sart-Tilman, 4000 
      Liege, Belgium. Etienne.cavalier@chu.ulg.ac.be
FAU - Delanaye, P
AU  - Delanaye P
FAU - Souberbielle, J-C
AU  - Souberbielle JC
FAU - Radermecker, R-P
AU  - Radermecker RP
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110222
PL  - France
TA  - Diabetes Metab
JT  - Diabetes & metabolism
JID - 9607599
RN  - 1406-16-2 (Vitamin D)
SB  - IM
MH  - Diabetes Mellitus, Type 2/epidemiology/*metabolism
MH  - Humans
MH  - Vitamin D/*metabolism
MH  - Vitamin D Deficiency/epidemiology/*metabolism
EDAT- 2011/02/25 06:00
MHDA- 2012/03/23 06:00
CRDT- 2011/02/25 06:00
PHST- 2011/01/03 00:00 [received]
PHST- 2011/01/05 00:00 [revised]
PHST- 2011/01/08 00:00 [accepted]
PHST- 2011/02/25 06:00 [entrez]
PHST- 2011/02/25 06:00 [pubmed]
PHST- 2012/03/23 06:00 [medline]
AID - S1262-3636(11)00008-5 [pii]
AID - 10.1016/j.diabet.2011.01.001 [doi]
PST - ppublish
SO  - Diabetes Metab. 2011 Sep;37(4):265-72. doi: 10.1016/j.diabet.2011.01.001. Epub 
      2011 Feb 22.