PMID- 21346723
OWN - NLM
STAT- MEDLINE
DCOM- 20110913
LR  - 20220409
IS  - 1523-1755 (Electronic)
IS  - 0085-2538 (Linking)
VI  - 79
IP  - 11
DP  - 2011 Jun
TI  - The possible role of ChemR23/Chemerin axis in the recruitment of dendritic cells 
      in lupus nephritis.
PG  - 1228-35
LID - 10.1038/ki.2011.32 [doi]
AB  - Dendritic cells (DCs) have a pivotal role in the autoimmune response of systemic 
      lupus erythematosus. Plasmacytoid DCs infiltrate the kidney of patients with 
      lupus nephritis, but factors regulating their recruitment to the kidney are 
      unknown. Chemerin is the recently identified natural ligand of ChemR23, a 
      receptor highly expressed by plasmacytoid DCs. We performed immunohistochemical 
      and immunofluorescence analysis to study the ChemR23/Chemerin axis in renal 
      biopsies from patients with lupus nephritis. We found ChemR23-positive DCs had 
      infiltrated the kidney tubulointerstitium in patients with severe lupus 
      nephritis. Chemerin association with tubular epithelial cells and renal lymphatic 
      endothelial cells was found in patients with lupus nephritis but not in normal 
      kidneys. Proximal tubular epithelial cells produced Chemerin in vitro, which was 
      significantly down-modulated by added tumor necrosis factor (TNF)-alpha and 
      interferon-gamma as measured by quantitative PCR and enzyme-linked immunosorbent 
      assay. Interestingly, TNF-alpha was capable of inducing a functionally active form of 
      renal Chemerin, resulting in an efficient transendothelial migration of 
      plasmacytoid DCs measured in transwell systems. Thus, the ChemR23/Chemerin axis 
      may have a role in the recruitment of DCs within the kidney in patients affected 
      by lupus nephritis.
FAU - De Palma, Giuseppe
AU  - De Palma G
AD  - Department of Emergency and Organ Transplantation, Nephrology, Dialysis, and 
      Transplantation Unit, University of Bari, Italy.
FAU - Castellano, Giuseppe
AU  - Castellano G
FAU - Del Prete, Annalisa
AU  - Del Prete A
FAU - Sozzani, Silvano
AU  - Sozzani S
FAU - Fiore, Nicoletta
AU  - Fiore N
FAU - Loverre, Antonia
AU  - Loverre A
FAU - Parmentier, Marc
AU  - Parmentier M
FAU - Gesualdo, Loreto
AU  - Gesualdo L
FAU - Grandaliano, Giuseppe
AU  - Grandaliano G
FAU - Schena, Francesco P
AU  - Schena FP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110223
PL  - United States
TA  - Kidney Int
JT  - Kidney international
JID - 0323470
RN  - 0 (CMKLR1 protein, human)
RN  - 0 (Chemokines)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (RARRES2 protein, human)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Chemokine)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Biopsy
MH  - Case-Control Studies
MH  - Cells, Cultured
MH  - Chemokines/genetics/*metabolism
MH  - *Chemotaxis
MH  - Coculture Techniques
MH  - Dendritic Cells/*immunology
MH  - Endothelial Cells/immunology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Epithelial Cells/immunology/pathology
MH  - Fluorescent Antibody Technique
MH  - Humans
MH  - Immunohistochemistry
MH  - Intercellular Signaling Peptides and Proteins
MH  - Interferon-gamma/metabolism
MH  - Kidney/*immunology/pathology
MH  - Kidney Tubules, Proximal/immunology/pathology
MH  - Lupus Nephritis/*immunology/pathology
MH  - RNA, Messenger/metabolism
MH  - Receptors, Chemokine/*metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Severity of Illness Index
MH  - *Signal Transduction
MH  - Time Factors
MH  - *Transendothelial and Transepithelial Migration
MH  - Tumor Necrosis Factor-alpha/metabolism
EDAT- 2011/02/25 06:00
MHDA- 2011/09/14 06:00
CRDT- 2011/02/25 06:00
PHST- 2011/02/25 06:00 [entrez]
PHST- 2011/02/25 06:00 [pubmed]
PHST- 2011/09/14 06:00 [medline]
AID - S0085-2538(15)54729-7 [pii]
AID - 10.1038/ki.2011.32 [doi]
PST - ppublish
SO  - Kidney Int. 2011 Jun;79(11):1228-35. doi: 10.1038/ki.2011.32. Epub 2011 Feb 23.