PMID- 21347087 OWN - NLM STAT- MEDLINE DCOM- 20160422 LR - 20211203 IS - 1942-597X (Electronic) IS - 1559-4076 (Linking) VI - 2010 DP - 2010 Nov 13 TI - A neighborhood susceptibility index for planning of local physical interventions in response to pandemic influenza outbreaks. PG - 792-6 AB - The global spread of a novel A (H1N1) influenza virus in 2009 has highlighted the possibility of a devastating pandemic similar to the 'Spanish flu' of 1917-1918. Responding to such pandemics requires careful planning for the early phases where there is no availability of pandemic vaccine. We set out to compute a Neighborhood Influenza Susceptibility Index (NISI) describing the vulnerability of local communities of different geo-socio-physical structure to a pandemic influenza outbreak. We used a spatially explicit geo-physical model of Linkoping municipality (pop. 136,240) in Sweden, and employed an ontology-modeling tool to define simulation models and transmission settings. We found considerable differences in NISI between neighborhoods corresponding to primary care areas with regard to early progress of the outbreak, as well as in terms of the total accumulated share of infected residents counted after the outbreak. The NISI can be used in local preparations of physical response measures during pandemics. FAU - Timpka, Toomas AU - Timpka T AD - Department of Medical and Health Sciences, Linkoping University, Linkoping, Sweden; FAU - Eriksson, Henrik AU - Eriksson H FAU - Stromgren, Magnus AU - Stromgren M FAU - Eriksson, Olle AU - Eriksson O FAU - Ekberg, Joakim AU - Ekberg J FAU - Grimvall, Anders AU - Grimvall A FAU - Nyce, James AU - Nyce J FAU - Gursky, Elin AU - Gursky E FAU - Holm, Einar AU - Holm E LA - eng PT - Journal Article DEP - 20101113 PL - United States TA - AMIA Annu Symp Proc JT - AMIA ... Annual Symposium proceedings. AMIA Symposium JID - 101209213 SB - IM MH - Disease Outbreaks MH - Hispanic or Latino MH - Humans MH - *Influenza A Virus, H1N1 Subtype MH - *Influenza, Human/epidemiology MH - Pandemics MH - Primary Health Care PMC - PMC3041303 EDAT- 2011/02/25 06:00 MHDA- 2016/04/23 06:00 PMCR- 2010/01/01 CRDT- 2011/02/25 06:00 PHST- 2011/02/25 06:00 [entrez] PHST- 2011/02/25 06:00 [pubmed] PHST- 2016/04/23 06:00 [medline] PHST- 2010/01/01 00:00 [pmc-release] AID - amia-2010_sympproc_0792 [pii] PST - epublish SO - AMIA Annu Symp Proc. 2010 Nov 13;2010:792-6.