PMID- 21347559
OWN - NLM
STAT- MEDLINE
DCOM- 20111013
LR  - 20211020
IS  - 1573-2568 (Electronic)
IS  - 0163-2116 (Linking)
VI  - 56
IP  - 8
DP  - 2011 Aug
TI  - Acute pancreatitis in obesity: adipokines and dietary fish oil.
PG  - 2318-25
LID - 10.1007/s10620-011-1626-x [doi]
AB  - BACKGROUND: Acute pancreatitis is a substantial clinical problem accounting for 
      240,000 hospital admissions yearly in the United States. Obesity is epidemic and 
      is clearly an independent risk factor for increased severity of acute 
      pancreatitis (AP). Adipose tissue is an endocrine organ that secretes a variety 
      of metabolically active substances termed adipokines. However, the role of 
      adipokines in modulating acute pancreatitis severity remains incompletely 
      understood. Dietary fish oil is rich in omega-3 free fatty acids and attenuates 
      adipose tissue-induced inflammation. Therefore, we hypothesized that feeding 
      obese mice diets rich in fish oil would alter the adipokine milieu and attenuate 
      the severity of pancreatitis. METHODS: Lean (C57BL/6 J) and obese (LepDb) mice 
      were fed either a soybean oil- or fish oil-rich diet for 4 weeks. AP was induced 
      by six hourly intraperitoneal injections of cerulein (50 mug/kg). Serum adipokine 
      levels were measured, and pancreatitis severity was assessed histologically and 
      by measuring pancreatic concentrations of interleukin-1 beta (IL-1beta), 
      interleukin-6 (IL-6), myleoperoxidase (MPO), and monocyte chemoattractant 
      protein-1 (MCP-1). RESULTS: Obese mice developed more severe pancreatitis than 
      lean mice. Fish oil significantly decreased serum leptin (lean and obese) and 
      increased serum adiponectin (lean only). Fish oil did not alter the baseline 
      pancreatic inflammatory milieu, nor did it change histologic or biochemical 
      pancreatitis severity. CONCLUSION: These data demonstrate that a diet rich in 
      fish oil altered the adipokine milieu in lean and congenitally obese mice; 
      however, fish oil did not improve pancreatitis severity induced with cerulein 
      hyperstimulation.
FAU - Al-Azzawi, Hayder H
AU  - Al-Azzawi HH
AD  - Department of Surgery, Indiana University School of Medicine, 535 Barnhill Drive, 
      RT 130, Indianapolis, IN 46202, USA.
FAU - Wade, Terence E
AU  - Wade TE
FAU - Swartz-Basile, Deborah A
AU  - Swartz-Basile DA
FAU - Wang, Sue
AU  - Wang S
FAU - Pitt, Henry A
AU  - Pitt HA
FAU - Zyromski, Nicholas J
AU  - Zyromski NJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110224
PL  - United States
TA  - Dig Dis Sci
JT  - Digestive diseases and sciences
JID - 7902782
RN  - 0 (Adipokines)
RN  - 0 (Adiponectin)
RN  - 0 (Ccl2 protein, mouse)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Dietary Fats, Unsaturated)
RN  - 0 (Fish Oils)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Interleukin-6)
RN  - 0 (Leptin)
RN  - 53608-75-6 (Pancrelipase)
RN  - 8001-22-7 (Soybean Oil)
RN  - 888Y08971B (Ceruletide)
RN  - EC 1.11.1.7 (Peroxidase)
SB  - IM
MH  - Adipokines/*blood
MH  - Adiponectin/blood
MH  - Animals
MH  - Ceruletide/adverse effects
MH  - Chemokine CCL2/blood
MH  - Dietary Fats, Unsaturated/*administration & dosage/metabolism
MH  - Female
MH  - Fish Oils/*administration & dosage/metabolism
MH  - Interleukin-1beta/blood
MH  - Interleukin-6/blood
MH  - Leptin/blood
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Obesity/*complications
MH  - Pancreatitis/*diet therapy/*etiology
MH  - Pancrelipase/chemistry
MH  - Peroxidase/blood
MH  - Severity of Illness Index
MH  - Soybean Oil/administration & dosage/metabolism
EDAT- 2011/02/25 06:00
MHDA- 2011/10/14 06:00
CRDT- 2011/02/25 06:00
PHST- 2010/12/21 00:00 [received]
PHST- 2011/02/07 00:00 [accepted]
PHST- 2011/02/25 06:00 [entrez]
PHST- 2011/02/25 06:00 [pubmed]
PHST- 2011/10/14 06:00 [medline]
AID - 10.1007/s10620-011-1626-x [doi]
PST - ppublish
SO  - Dig Dis Sci. 2011 Aug;56(8):2318-25. doi: 10.1007/s10620-011-1626-x. Epub 2011 
      Feb 24.