PMID- 21347598 OWN - NLM STAT- MEDLINE DCOM- 20120619 LR - 20211020 IS - 1875-8312 (Electronic) IS - 1569-5794 (Print) IS - 1569-5794 (Linking) VI - 28 IP - 2 DP - 2012 Feb TI - Cardiac magnetic resonance visualizes acute and chronic myocardial injuries in myocarditis. PG - 327-35 LID - 10.1007/s10554-011-9812-7 [doi] AB - Our objective was to evaluate the ability of CMR to visualize myocardial injuries over the course of myocarditis. We studied 42 patients (39 males, 3 females; age 37 +/- 14 years) with myocarditis during the acute phase and after 12 +/- 9 months. CMR included function analyses, T2-weighted imaging (T2 ratio), T1-weighted imaging before and after i.v. gadolinium injection (global relative enhancement; gRE), and late gadolinium enhancement (LGE). In the acute phase, the T2 ratio was elevated in 57%, gRE in 31%, and LGE was present in 64% of the patients. In 32 patients (76%) were any two (or more) out of three sequences abnormal. At follow-up, there was an increase in ejection fraction (57.4 +/- 11.9% vs. 61.4 +/- 7.6; P < 0.05) while both T2 ratio (2.04 +/- 0.32 vs. 1.70 +/- 0.28; P < 0.001) and gRE (4.07 +/- 1.63 vs. 3.11 +/- 1.22; P < 0.05) significantly decreased. The LGE persisted in 10 patients. Dilated cardiomyopathy was present in 3 patients and 4 patients received a defibrillator or a pacemaker. A comprehensive CMR approach is a useful tool to visualize myocardial tissue injuries over the course of myocarditis. CMR may help to differentiate acute from healed myocarditis, and add information for the differential diagnoses. FAU - Stensaeth, Knut Haakon AU - Stensaeth KH AD - Department of Radiology, Oslo University Hospital, Ullevaal, Oslo, Norway. k.h.stensath@medisin.uio.no FAU - Hoffmann, Pavel AU - Hoffmann P FAU - Fossum, Eigil AU - Fossum E FAU - Mangschau, Arild AU - Mangschau A FAU - Sandvik, Leiv AU - Sandvik L FAU - Klow, Nils Einar AU - Klow NE LA - eng PT - Evaluation Study PT - Journal Article DEP - 20110224 PL - United States TA - Int J Cardiovasc Imaging JT - The international journal of cardiovascular imaging JID - 100969716 RN - 0 (Contrast Media) RN - K2I13DR72L (Gadolinium DTPA) SB - IM MH - Adult MH - Chi-Square Distribution MH - Contrast Media MH - Diagnosis, Differential MH - Female MH - Gadolinium DTPA MH - Humans MH - *Magnetic Resonance Imaging MH - Male MH - Middle Aged MH - Myocarditis/complications/*diagnosis/pathology/physiopathology MH - Myocardium/*pathology MH - Norway MH - Predictive Value of Tests MH - Prognosis MH - Prospective Studies MH - Retrospective Studies MH - Stroke Volume MH - Time Factors MH - Ventricular Function, Left MH - Young Adult PMC - PMC3288366 EDAT- 2011/02/25 06:00 MHDA- 2012/06/20 06:00 PMCR- 2011/02/24 CRDT- 2011/02/25 06:00 PHST- 2010/10/05 00:00 [received] PHST- 2011/01/17 00:00 [accepted] PHST- 2011/02/25 06:00 [entrez] PHST- 2011/02/25 06:00 [pubmed] PHST- 2012/06/20 06:00 [medline] PHST- 2011/02/24 00:00 [pmc-release] AID - 9812 [pii] AID - 10.1007/s10554-011-9812-7 [doi] PST - ppublish SO - Int J Cardiovasc Imaging. 2012 Feb;28(2):327-35. doi: 10.1007/s10554-011-9812-7. Epub 2011 Feb 24.