PMID- 21348313
OWN - NLM
STAT- MEDLINE
DCOM- 20120919
LR  - 20181201
IS  - 0513-4870 (Print)
IS  - 0513-4870 (Linking)
VI  - 45
IP  - 10
DP  - 2010 Oct
TI  - [Oral cavity delivery system of unfractionated and low molecular weight heparin].
PG  - 1317-21
AB  - The difference between absorption of unfractionated heparin (UFH) and low 
      molecular weight heparin (LMWH) after oral and oral cavity administration were 
      studied respectively, and the compatible enhancer for oral cavity delivery system 
      of both drugs was found. The LMWH and UFH films were prepared with two 
      bioadhesive materials Carbopol and alginate sodium for oral cavity delivery. The 
      activated partial thromboplastin time (APTT) was used to determine LMWH and UFH 
      in plasma after oral, oral cavity and sc administration in rats. The results show 
      that the enhancer (Labrasol) can increase the absorption of LMWH and UFH through 
      oral cavity in rats but not obviously. The oral cavity iontophoretic delivery 
      system is a useful method to improve the absorption of LMWH and UFH through oral 
      cavity mucosa.
FAU - Li, Ding
AU  - Li D
AD  - National Pharmaceutical Engineering & Research Center Shanghai 201203, China.
FAU - Hou, Hui-min
AU  - Hou HM
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Yao Xue Xue Bao
JT  - Yao xue xue bao = Acta pharmaceutica Sinica
JID - 21710340R
RN  - 0 (Acrylic Resins)
RN  - 0 (Alginates)
RN  - 0 (Anticoagulants)
RN  - 0 (Drug Carriers)
RN  - 0 (Glycerides)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 0 (Hexuronic Acids)
RN  - 0 (Organic Chemicals)
RN  - 0 (Polyvinyls)
RN  - 00BT03FSO2 (Labrasol)
RN  - 0A5MM307FC (carboxypolymethylene)
RN  - 8A5D83Q4RW (Glucuronic Acid)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Absorption
MH  - Acrylic Resins
MH  - Administration, Oral
MH  - Alginates/chemistry
MH  - Animals
MH  - Anticoagulants/administration & dosage/pharmacokinetics
MH  - Drug Carriers
MH  - Drug Delivery Systems
MH  - Glucuronic Acid/chemistry
MH  - Glycerides
MH  - Heparin/*administration & dosage/*pharmacokinetics
MH  - Heparin, Low-Molecular-Weight/*administration & dosage/*pharmacokinetics
MH  - Hexuronic Acids/chemistry
MH  - Injections, Intradermal
MH  - Iontophoresis
MH  - Male
MH  - Mouth
MH  - Organic Chemicals/pharmacology
MH  - Partial Thromboplastin Time
MH  - Polyvinyls/chemistry
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2011/02/26 06:00
MHDA- 2012/09/20 06:00
CRDT- 2011/02/26 06:00
PHST- 2011/02/26 06:00 [entrez]
PHST- 2011/02/26 06:00 [pubmed]
PHST- 2012/09/20 06:00 [medline]
PST - ppublish
SO  - Yao Xue Xue Bao. 2010 Oct;45(10):1317-21.