PMID- 21348543
OWN - NLM
STAT- MEDLINE
DCOM- 20110620
LR  - 20160707
IS  - 1179-1888 (Electronic)
IS  - 1175-0561 (Linking)
VI  - 12
IP  - 2
DP  - 2011 Apr 1
TI  - Response to narrow-band UVB--vitiligo-melasma versus vitiligo: a comparative 
      study.
PG  - 127-32
LID - 10.2165/11537120-000000000-00000 [doi]
AB  - BACKGROUND: Vitiligo is the most common depigmentary disorder of the skin and 
      hair, resulting from selective destruction of melanocytes. Melasma, a 
      hyperpigmentary disorder, presents as irregular, brown, macular hypermelanosis. A 
      small subset of vitiligo patients paradoxically also have melasma. OBJECTIVE: To 
      evaluate and compare the response to narrow-band UVB in a group of patients with 
      vitiligo, and another group of patients with vitiligo and coexisting melasma 
      (vitiligo-melasma). METHODS: Patients in both groups were treated with 
      narrow-band UVB and a comparison of the zonal repigmentation was made at 4, 8, 
      and 12 weeks after the initiation of therapy. RESULTS: At the end of 12 weeks, 
      86% of patients in the vitiligo-melasma group attained >/=75% pigmentation on the 
      face, whereas this was achieved in only 12.5% of patients in the vitiligo group. 
      Over the limbs, 73% of patients in the vitiligo-melasma group attained 75% or 
      more pigmentation at the end of 12 weeks compared with only 9% in the vitiligo 
      group. On the trunk, only 20% of vitiligo-melasma patients showed >/=75% 
      pigmentation at 12 weeks compared with 63% of patients in the vitiligo group. 
      CONCLUSION: Patients having both vitiligo and melasma have a significantly better 
      prognosis for repigmentation on the face and limbs with narrow-band UVB compared 
      with patients with vitiligo alone; the vitiligo-melasma patients achieve 
      repigmentation much earlier and also attain a greater level of repigmentation. 
      Unexpectedly, for truncal lesions, patients with vitiligo alone responded better 
      than those with both conditions. Although the vitiligo-melasma group with truncal 
      lesions started repigmenting earlier, the final pigmentation was more extensive 
      in the vitiligo group.
FAU - Sharma, Parikshit
AU  - Sharma P
AD  - Department of Dermatology, Kasturba Medical College, Mangalore, India. 
      drparikshit_sharma@yahoo.com
FAU - Pai, Harsha S
AU  - Pai HS
FAU - Pai, Ganesh S
AU  - Pai GS
FAU - Kuruvila, Maria
AU  - Kuruvila M
FAU - Kolar, Reshma
AU  - Kolar R
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
PL  - New Zealand
TA  - Am J Clin Dermatol
JT  - American journal of clinical dermatology
JID - 100895290
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Extremities
MH  - Face
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Melanosis/complications/pathology/*radiotherapy
MH  - Middle Aged
MH  - Prognosis
MH  - Skin Pigmentation
MH  - Treatment Outcome
MH  - Ultraviolet Therapy/*methods
MH  - Vitiligo/complications/pathology/*radiotherapy
MH  - Young Adult
EDAT- 2011/02/26 06:00
MHDA- 2011/06/21 06:00
CRDT- 2011/02/26 06:00
PHST- 2011/02/26 06:00 [entrez]
PHST- 2011/02/26 06:00 [pubmed]
PHST- 2011/06/21 06:00 [medline]
AID - 4 [pii]
AID - 10.2165/11537120-000000000-00000 [doi]
PST - ppublish
SO  - Am J Clin Dermatol. 2011 Apr 1;12(2):127-32. doi: 
      10.2165/11537120-000000000-00000.