PMID- 21348878
OWN - NLM
STAT- MEDLINE
DCOM- 20110404
LR  - 20151119
IS  - 1753-4887 (Electronic)
IS  - 0029-6643 (Linking)
VI  - 69
IP  - 3
DP  - 2011 Mar
TI  - Reliability of leptin, but not adiponectin, as a biomarker for diet-induced 
      weight loss in humans.
PG  - 145-54
LID - 10.1111/j.1753-4887.2011.00373.x [doi]
AB  - Calorie restriction (CR)-induced weight loss has been shown to lower the risk of 
      chronic disease in obese individuals. Although the mechanisms that link weight 
      loss to disease risk reduction remain unclear, evidence suggests adipokines may 
      play a role. What has yet to be determined, however, is the dose-response effect 
      of body weight loss and visceral fat mass loss on adipokines. Accordingly, this 
      review examines how varying degrees of CR-induced weight loss (i.e., >10%, 5-10%, 
      and <5% from baseline) impact plasma levels and expression of adiponectin, 
      leptin, resistin, interleukin 6 (IL-6), interleukin 8 (IL-8), monocyte 
      chemotactic protein 1 (MCP-1), and retinol-binding protein 4 (RBP-4). The 
      dose-response relationship between visceral fat mass loss and adipokine profile 
      improvement will also be explored. Results from this review demonstrate that even 
      mild weight loss induced by CR may have beneficial effects on leptin levels, but 
      it has no clear impact on adiponectin, resistin, IL-6, IL-8, MCP-1, or RBP-4 
      concentrations.
CI  - (c) 2011 International Life Sciences Institute.
FAU - Klempel, Monica C
AU  - Klempel MC
AD  - Department of Kinesiology and Nutrition, University of Illinois at Chicago, 
      Chicago, Illinois 60612, USA. varady@uic.edu
FAU - Varady, Krista A
AU  - Varady KA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110214
PL  - United States
TA  - Nutr Rev
JT  - Nutrition reviews
JID - 0376405
RN  - 0 (Adiponectin)
RN  - 0 (Biomarkers)
RN  - 0 (Leptin)
SB  - IM
MH  - Adiponectin/*blood
MH  - Biomarkers/blood
MH  - Caloric Restriction
MH  - Humans
MH  - Leptin/*blood
MH  - Obesity/*blood/*diet therapy
MH  - *Weight Loss
EDAT- 2011/02/26 06:00
MHDA- 2011/04/05 06:00
CRDT- 2011/02/26 06:00
PHST- 2011/02/26 06:00 [entrez]
PHST- 2011/02/26 06:00 [pubmed]
PHST- 2011/04/05 06:00 [medline]
AID - 10.1111/j.1753-4887.2011.00373.x [doi]
PST - ppublish
SO  - Nutr Rev. 2011 Mar;69(3):145-54. doi: 10.1111/j.1753-4887.2011.00373.x. Epub 2011 
      Feb 14.