PMID- 21348957
OWN - NLM
STAT- MEDLINE
DCOM- 20110606
LR  - 20211020
IS  - 1752-8062 (Electronic)
IS  - 1752-8054 (Print)
IS  - 1752-8054 (Linking)
VI  - 4
IP  - 1
DP  - 2011 Feb
TI  - Familial isolated pituitary adenomas: from genetics to therapy.
PG  - 55-62
LID - 10.1111/j.1752-8062.2010.00254.x [doi]
AB  - According to autopsy and radiological data, pituitary adenomas (PAs) develop in 
      approximately 15% to 20% of the population. The great majority of PAs arise 
      sporadically and affect adults. Rarely they are diagnosed in children and 
      adolescents. Approximately 5% of cases are thought to be familial. Inherited 
      conditions associated with pituitary tumors include multiple endocrine neoplasia 
      type 1 (MEN-1) and type 4 (MEN-4), (CNC) Carney Complex, and familial isolated PA 
      (FIPA) syndrome. FIPA is an autosomal dominant condition, defined by the presence 
      of two or more patients affected by PAs in the same kindred, and no other 
      associated condition. Germline mutations of the aryl hydrocarbon receptor 
      interacting protein gene located on chromosome 11q13 have been reported in 
      15%-40% of FIPA cases. In the remaining cases, genetic defect are unidentified. 
      This article focuses on FIPA clinical, pathological, genetic features, and 
      therapeutic management.
CI  - (c) 2011 Wiley Periodicals, Inc.
FAU - Guaraldi, Federica
AU  - Guaraldi F
AD  - Department of Pathology, The Johns Hopkins School of Medicine, Baltimore, 
      Maryland, USA.
FAU - Salvatori, Roberto
AU  - Salvatori R
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Clin Transl Sci
JT  - Clinical and translational science
JID - 101474067
SB  - IM
MH  - Family
MH  - Genes, Neoplasm/genetics
MH  - Humans
MH  - Pituitary Neoplasms/*genetics/pathology/*therapy
PMC - PMC5439841
EDAT- 2011/02/26 06:00
MHDA- 2011/06/07 06:00
PMCR- 2011/02/01
CRDT- 2011/02/26 06:00
PHST- 2011/02/26 06:00 [entrez]
PHST- 2011/02/26 06:00 [pubmed]
PHST- 2011/06/07 06:00 [medline]
PHST- 2011/02/01 00:00 [pmc-release]
AID - CTS254 [pii]
AID - 10.1111/j.1752-8062.2010.00254.x [doi]
PST - ppublish
SO  - Clin Transl Sci. 2011 Feb;4(1):55-62. doi: 10.1111/j.1752-8062.2010.00254.x.