PMID- 21349213
OWN - NLM
STAT- MEDLINE
DCOM- 20110826
LR  - 20131121
IS  - 1475-2662 (Electronic)
IS  - 0007-1145 (Linking)
VI  - 105
IP  - 11
DP  - 2011 Jun
TI  - High-glycaemic index and -glycaemic load meals increase the availability of 
      tryptophan in healthy volunteers.
PG  - 1601-6
LID - 10.1017/S0007114510005192 [doi]
AB  - The purpose of the present study was to determine the influence of the glycaemic 
      index (GI) and glycaemic load (GL) on the ratio of tryptophan (TRP) relative to 
      other large neutral amino acids (LNAA). Ten healthy men (age 22.9 (sd 3.4) years; 
      BMI 23.5 (sd 1.6) kg/m2) underwent standard GI testing, and later consumed each 
      of a mixed-macronutrient (1915 kJ; 66.5 % carbohydrate (CHO), 17 % protein and 
      16.5 % fat) high-GI (MHGI), an isoenergetic, mixed-macronutrient low-GI (MLGI) 
      and a CHO-only (3212 kJ; 90 % CHO, 8 % protein, 2 % fat) high-GI (CHGI) meal on 
      separate days. The GI, GL and insulin index values (e.g. area under the curve) 
      were largest after the CHGI meal (117, 200, 158), followed by the MHGI (79, 59, 
      82) and MLGI (51, 38, 56) meals, respectively (all values were significantly 
      different, P < 0.05). After the MHGI and MLGI meals but not after the CHGI meal, 
      TRP was elevated at 120 and 180 min (P < 0.05). After the CHGI, LNAA was lower 
      compared with the MLGI (P < 0.05); also the rate of decline in LNAA was higher 
      after CHGI compared with MHGI and MLGI (both comparisons P < 0.05). The 
      percentage increase from baseline in TRP:LNAA after CHGI (23 %) was only 
      marginally higher than after the MHGI meal (17 %; P = 0.38), but it was threefold 
      and nearly significantly greater than MLGI (8 %; P = 0.05). The present study 
      demonstrates that the postprandial rise in TRP:LNAA was increased by additional 
      CHO ingestion and higher GI. Therefore, the meal GL appears to be an important 
      factor influencing the postprandial TRP:LNAA concentration.
FAU - Herrera, Christopher P
AU  - Herrera CP
AD  - Discipline of Exercise and Sport Science, Faculty of Health Sciences, University 
      of Sydney, Sydney, NSW, Australia. christopher.herrera@aspetar.com
FAU - Smith, Keir
AU  - Smith K
FAU - Atkinson, Fiona
AU  - Atkinson F
FAU - Ruell, Patricia
AU  - Ruell P
FAU - Chow, Chin Moi
AU  - Chow CM
FAU - O'Connor, Helen
AU  - O'Connor H
FAU - Brand-Miller, Jennie
AU  - Brand-Miller J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110224
PL  - England
TA  - Br J Nutr
JT  - The British journal of nutrition
JID - 0372547
RN  - 0 (Amino Acids)
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Insulin)
RN  - 8DUH1N11BX (Tryptophan)
SB  - IM
MH  - Adult
MH  - Amino Acids/blood
MH  - Biological Availability
MH  - Blood Glucose/metabolism
MH  - Dietary Carbohydrates/administration & dosage/*metabolism
MH  - Food Analysis
MH  - *Glycemic Index
MH  - Humans
MH  - Insulin/blood/metabolism
MH  - Male
MH  - Postprandial Period
MH  - Satiety Response
MH  - Sleep Stages
MH  - Tryptophan/blood/*pharmacokinetics
MH  - Young Adult
EDAT- 2011/02/26 06:00
MHDA- 2011/08/30 06:00
CRDT- 2011/02/26 06:00
PHST- 2011/02/26 06:00 [entrez]
PHST- 2011/02/26 06:00 [pubmed]
PHST- 2011/08/30 06:00 [medline]
AID - S0007114510005192 [pii]
AID - 10.1017/S0007114510005192 [doi]
PST - ppublish
SO  - Br J Nutr. 2011 Jun;105(11):1601-6. doi: 10.1017/S0007114510005192. Epub 2011 Feb 
      24.