PMID- 21349736
OWN - NLM
STAT- MEDLINE
DCOM- 20120113
LR  - 20221207
IS  - 1873-734X (Electronic)
IS  - 1010-7940 (Linking)
VI  - 40
IP  - 1
DP  - 2011 Jul
TI  - Overexpression of interleukin-1beta and interferon-gamma in type I thoracic aortic 
      dissections and ascending thoracic aortic aneurysms: possible correlation with 
      matrix metalloproteinase-9 expression and apoptosis of aortic media cells.
PG  - 17-22
LID - 10.1016/j.ejcts.2010.09.019 [doi]
AB  - OBJECTIVE: To examine the expression of interleukin-1beta and interferon-gamma and their 
      possible roles in aortic dissections and aneurysms. METHODS: Aortic specimens 
      were obtained from patients with type I thoracic aortic dissection, ascending 
      thoracic aortic aneurysms, and control organ donors. The expression of 
      interleukin-1beta, interferon-gamma, matrix metalloproteinase-9, and signal transduction 
      factors phospho-p38 and phosphorylated c-jun N-terminal kinase (phospho-JNK) were 
      detected by real time reverse transcription-polymerase chain reaction (real time 
      RT-PCR), Western blot, and immunohistochemistry, respectively. Terminal 
      deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) staining was 
      performed to detect apoptosis of media cells. The correlation of these factors 
      and apoptosis was also studied. RESULTS: Apoptosis in the media of thoracic 
      aortic dissection and in ascending thoracic aortic aneurysms was dramatically 
      higher than in the control group. The expression of interleukin-1beta gradually 
      increased from the control group, thoracic aortic dissection to ascending 
      thoracic aortic aneurysms (p < 0.01, respectively). The expression of 
      interferon-gamma and matrix metalloproteinase-9 was significantly increased in the 
      media of thoracic aortic dissection and ascending thoracic aortic aneurysms 
      compared with the control group (p < 0.01, respectively). There were positive 
      correlations between interleukin-1beta versus matrix metalloproteinase-9, 
      interleukin-1beta versus phospho-p38 in thoracic aortic dissection (p < 0.01, 
      respectively), and interferon-gamma versus matrix metalloproteinase-9, interferon-gamma 
      versus phospho-JNK, interferon-gamma versus apoptosis, and interleukin-1beta versus 
      apoptosis in ascending thoracic aortic aneurysms (p = 0.02, 0.02, p < 0.01, p < 
      0.01). CONCLUSIONS: Interleukin-1beta and interferon-gamma might effect the formation of 
      thoracic aortic dissection and ascending thoracic aortic aneurysms possibly 
      through the up-regulation of matrix metalloproteinase-9 and the apoptosis of 
      media cells in humans.
CI  - Copyright (c) 2010 European Association for Cardio-Thoracic Surgery. Published by 
      Elsevier B.V. All rights reserved.
FAU - Zhang, Lei
AU  - Zhang L
AD  - Department of Vascular Surgery, Changhai Hospital, Second Military Medical 
      University, 168 Changhai Road, Shanghai 200433, China.
FAU - Liao, Ming-fang
AU  - Liao MF
FAU - Tian, Lei
AU  - Tian L
FAU - Zou, Si-li
AU  - Zou SL
FAU - Lu, Qing-sheng
AU  - Lu QS
FAU - Bao, Jun-min
AU  - Bao JM
FAU - Pei, Yi-fei
AU  - Pei YF
FAU - Jing, Zai-ping
AU  - Jing ZP
LA  - eng
PT  - Journal Article
DEP - 20110223
PL  - Germany
TA  - Eur J Cardiothorac Surg
JT  - European journal of cardio-thoracic surgery : official journal of the European 
      Association for Cardio-thoracic Surgery
JID - 8804069
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Differentiation, Myelomonocytic)
RN  - 0 (Biomarkers)
RN  - 0 (CD4 Antigens)
RN  - 0 (CD68 antigen, human)
RN  - 0 (Interleukin-1beta)
RN  - 82115-62-6 (Interferon-gamma)
RN  - EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aortic Dissection/*metabolism/pathology
MH  - Antigens, CD/metabolism
MH  - Antigens, Differentiation, Myelomonocytic/metabolism
MH  - Aortic Aneurysm, Thoracic/*metabolism/pathology
MH  - Apoptosis/physiology
MH  - Biomarkers/metabolism
MH  - CD4 Antigens/metabolism
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Interferon-gamma/*metabolism
MH  - Interleukin-1beta/*metabolism
MH  - MAP Kinase Signaling System/physiology
MH  - Male
MH  - Matrix Metalloproteinase 9/*metabolism
MH  - Middle Aged
MH  - Real-Time Polymerase Chain Reaction/methods
MH  - Tunica Media/metabolism/pathology
MH  - p38 Mitogen-Activated Protein Kinases/metabolism
EDAT- 2011/02/26 06:00
MHDA- 2012/01/14 06:00
CRDT- 2011/02/26 06:00
PHST- 2010/06/04 00:00 [received]
PHST- 2010/09/01 00:00 [revised]
PHST- 2010/09/05 00:00 [accepted]
PHST- 2011/02/26 06:00 [entrez]
PHST- 2011/02/26 06:00 [pubmed]
PHST- 2012/01/14 06:00 [medline]
AID - S1010-7940(10)00781-5 [pii]
AID - 10.1016/j.ejcts.2010.09.019 [doi]
PST - ppublish
SO  - Eur J Cardiothorac Surg. 2011 Jul;40(1):17-22. doi: 10.1016/j.ejcts.2010.09.019. 
      Epub 2011 Feb 23.