PMID- 21350578
OWN - NLM
STAT- MEDLINE
DCOM- 20110408
LR  - 20211020
IS  - 1474-1741 (Electronic)
IS  - 1474-1733 (Print)
IS  - 1474-1733 (Linking)
VI  - 11
IP  - 3
DP  - 2011 Mar
TI  - DCs and NK cells: critical effectors in the immune response to HIV-1.
PG  - 176-86
LID - 10.1038/nri2935 [doi]
AB  - Dendritic cells (DCs) and natural killer (NK) cells have central roles in 
      antiviral immunity by shaping the quality of the adaptive immune response to 
      viruses and by mediating direct antiviral activity. HIV-1 infection is 
      characterized by a severe dysregulation of the antiviral immune response that 
      starts during early infection. This Review describes recent insights into how 
      HIV-1 infection affects DC and NK cell function, and the roles of these innate 
      immune cells in HIV-1 pathogenesis. The importance of understanding DC and NK 
      cell crosstalk during HIV infection for the development of effective antiviral 
      strategies is also discussed.
FAU - Altfeld, Marcus
AU  - Altfeld M
AD  - Ragon Institute of MGH, MIT and Harvard, Massachusetts General Hospital, 
      Charlestown, Massachusetts 02129, USA. maltfeld@partners.org
FAU - Fadda, Lena
AU  - Fadda L
FAU - Frleta, Davor
AU  - Frleta D
FAU - Bhardwaj, Nina
AU  - Bhardwaj N
LA  - eng
GR  - R01 AI081848/AI/NIAID NIH HHS/United States
GR  - U19 AI067854-07/AI/NIAID NIH HHS/United States
GR  - P01 AI074415/AI/NIAID NIH HHS/United States
GR  - U19 AI067854/AI/NIAID NIH HHS/United States
GR  - R01 AI078784-03/AI/NIAID NIH HHS/United States
GR  - P01 AI074415-05/AI/NIAID NIH HHS/United States
GR  - R37 AI044628/AI/NIAID NIH HHS/United States
GR  - R37 AI044628-14/AI/NIAID NIH HHS/United States
GR  - R01 AI081848-03/AI/NIAID NIH HHS/United States
GR  - R01 AI078784/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Nat Rev Immunol
JT  - Nature reviews. Immunology
JID - 101124169
RN  - 0 (AIDS Vaccines)
RN  - 0 (Antigens, CD)
RN  - 0 (CD207 protein, human)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (DC-specific ICAM-3 grabbing nonintegrin)
RN  - 0 (HIV Antigens)
RN  - 0 (HIV Envelope Protein gp120)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Mannose-Binding Lectins)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, HIV)
RN  - 0 (Receptors, KIR)
RN  - 0 (TLR8 protein, human)
RN  - 0 (Toll-Like Receptor 8)
RN  - 0 (gp120 protein, Human immunodeficiency virus 1)
SB  - IM
MH  - AIDS Vaccines/immunology
MH  - Adaptive Immunity/immunology
MH  - Animals
MH  - Antigen Presentation
MH  - Antigens, CD/metabolism
MH  - Autophagy
MH  - Cell Adhesion Molecules/metabolism
MH  - Cell Communication
MH  - Dendritic Cells/*immunology/virology
MH  - Female
MH  - HIV Antigens/immunology
MH  - HIV Envelope Protein gp120/metabolism
MH  - HIV Infections/*immunology
MH  - HIV-1/*immunology
MH  - Haplorhini
MH  - Humans
MH  - Killer Cells, Natural/*immunology
MH  - Lectins, C-Type/metabolism
MH  - Male
MH  - Mannose-Binding Lectins/metabolism
MH  - Receptors, Cell Surface/metabolism
MH  - Receptors, HIV/immunology/physiology
MH  - Receptors, KIR/immunology
MH  - Simian Acquired Immunodeficiency Syndrome/immunology
MH  - Simian Immunodeficiency Virus/immunology
MH  - Toll-Like Receptor 8/metabolism
MH  - Vaccination
PMC - PMC3278081
MID - NIHMS351430
EDAT- 2011/02/26 06:00
MHDA- 2011/04/09 06:00
PMCR- 2012/02/13
CRDT- 2011/02/26 06:00
PHST- 2011/02/26 06:00 [entrez]
PHST- 2011/02/26 06:00 [pubmed]
PHST- 2011/04/09 06:00 [medline]
PHST- 2012/02/13 00:00 [pmc-release]
AID - nri2935 [pii]
AID - 10.1038/nri2935 [doi]
PST - ppublish
SO  - Nat Rev Immunol. 2011 Mar;11(3):176-86. doi: 10.1038/nri2935.