PMID- 21350611
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Print)
IS  - 1741-427X (Linking)
VI  - 2011
DP  - 2011
TI  - Combination of Medicinal Herbs KIOM-79 Reduces Advanced Glycation End Product 
      Accumulation and the Expression of Inflammatory Factors in the Aorta of Zucker 
      Diabetic Fatty Rats.
PG  - 784136
LID - 10.1155/2011/784136 [doi]
LID - 784136
AB  - Previous studies have reported that KIOM-79 shows a strong inhibitory effect on 
      AGE formation and inhibited a proinflammatory state in a murine macrophage cell 
      line. In the present study, we investigated the effect of KIOM-79 on AGE 
      accumulation and vascular inflammation in the aorta of Zucker diabetic fatty 
      (ZDF) rats, a commonly used model of type 2 diabetes. Seven-week-old male ZDF 
      rats were treated with KIOM-79 (50 mg/kg) once a day orally for 13 weeks. We 
      examined the dissected aortas for AGE accumulation, expression of the receptor 
      for AGEs (RAGE), and the expression of proinflammatory factors, including 
      monocyte chemoattractant protein-1 (MCP-1), vascular endothelial growth factor 
      (VEGF), and vascular adhesion molecule-1 (VCAM-1). Nuclear factor-kappaB (NF-kappaB) 
      and inducible nitric oxide synthase (iNOS) were also measured by Southwestern 
      histochemistry, electrophoretic mobility shift assay (EMSA), and 
      immunohistochemistry, respectively. KIOM-79 markedly reduced the accumulation of 
      AGEs and the expression of RAGE in the aorta. We also found that KIOM-79 
      attenuated the expression of inflammatory factors including NF-kappaB, MCP-1, VEGF, 
      VCAM-1, and iNOS in the aortas of ZDF rats. These data suggest that KIOM-79 may 
      prevent or retard the development of inflammation in diabetic vascular disease.
FAU - Sohn, Eunjin
AU  - Sohn E
AD  - Diabetic Complications Research Center, Division of Traditional Korean Medicine 
      (TKM) Integrated Research, Korea Institute of Oriental Medicine (KIOM), 483 
      Exporo, Yuseong-gu, Daejeon 305-811, Republic of Korea.
FAU - Kim, Junghyun
AU  - Kim J
FAU - Jeong, Il Ha
AU  - Jeong IH
FAU - Kim, Chan Sik
AU  - Kim CS
FAU - Kim, Young Sook
AU  - Kim YS
FAU - Kim, Jin Sook
AU  - Kim JS
LA  - eng
PT  - Journal Article
DEP - 20110215
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC3042642
EDAT- 2011/02/26 06:00
MHDA- 2011/02/26 06:01
PMCR- 2011/02/15
CRDT- 2011/02/26 06:00
PHST- 2010/07/02 00:00 [received]
PHST- 2010/12/24 00:00 [revised]
PHST- 2011/01/03 00:00 [accepted]
PHST- 2011/02/26 06:00 [entrez]
PHST- 2011/02/26 06:00 [pubmed]
PHST- 2011/02/26 06:01 [medline]
PHST- 2011/02/15 00:00 [pmc-release]
AID - 10.1155/2011/784136 [doi]
PST - ppublish
SO  - Evid Based Complement Alternat Med. 2011;2011:784136. doi: 10.1155/2011/784136. 
      Epub 2011 Feb 15.