PMID- 21350792
OWN - NLM
STAT- MEDLINE
DCOM- 20110901
LR  - 20211020
IS  - 1129-2377 (Electronic)
IS  - 1129-2369 (Print)
IS  - 1129-2369 (Linking)
VI  - 12
IP  - 3
DP  - 2011 Jun
TI  - Optimal balance of efficacy and tolerability of oral triptans and telcagepant: a 
      review and a clinical comment.
PG  - 275-80
LID - 10.1007/s10194-011-0309-5 [doi]
AB  - Dose-response curves for headaches relief and adverse events (AEs) are presented 
      for five triptans: sumatriptan, zolmitriptan, naratriptan, almotriptan, and 
      frovatriptan, and the CGRP antagonist telcagepant. The upper part of the efficacy 
      curve of the triptans is generally flat, the so-called ceiling effect; and none 
      of the oral triptans, even in high doses, are as effective as subcutaneous 
      sumatriptan, In contrast, AEs increases with increasing dose without a ceiling 
      effect. The optimal dose for the triptans is mainly determined by tolerability. 
      Telcagepant has an excellent tolerability and can be used in migraine patients 
      with cardiovascular co-morbidity. Based on the literature the triptans and 
      telcagepant are rated in a table for efficacy and tolerability.
FAU - Tfelt-Hansen, Peer
AU  - Tfelt-Hansen P
AD  - Department of Neurology, Danish Headache Center, University of Copenhagen, 
      Glostrup Hospital, Glostrup, Denmark. ptha@glo.regionh.dk
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110225
PL  - England
TA  - J Headache Pain
JT  - The journal of headache and pain
JID - 100940562
RN  - 0 (Azepines)
RN  - 0 (Calcitonin Gene-Related Peptide Receptor Antagonists)
RN  - 0 (Imidazoles)
RN  - 0 (Serotonin 5-HT1 Receptor Agonists)
RN  - 0 (Tryptamines)
RN  - D42O649ALL (telcagepant)
SB  - IM
MH  - Azepines/*therapeutic use
MH  - *Calcitonin Gene-Related Peptide Receptor Antagonists
MH  - Humans
MH  - Imidazoles/*therapeutic use
MH  - Migraine Disorders/*drug therapy
MH  - Serotonin 5-HT1 Receptor Agonists/*therapeutic use
MH  - Tryptamines/*therapeutic use
PMC - PMC3094671
EDAT- 2011/02/26 06:00
MHDA- 2011/09/02 06:00
PMCR- 2011/02/25
CRDT- 2011/02/26 06:00
PHST- 2010/12/23 00:00 [received]
PHST- 2011/01/28 00:00 [accepted]
PHST- 2011/02/26 06:00 [entrez]
PHST- 2011/02/26 06:00 [pubmed]
PHST- 2011/09/02 06:00 [medline]
PHST- 2011/02/25 00:00 [pmc-release]
AID - 309 [pii]
AID - 10.1007/s10194-011-0309-5 [doi]
PST - ppublish
SO  - J Headache Pain. 2011 Jun;12(3):275-80. doi: 10.1007/s10194-011-0309-5. Epub 2011 
      Feb 25.