PMID- 21352358
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20110706
IS  - 1651-2227 (Electronic)
IS  - 0803-5253 (Linking)
VI  - 100
IP  - 8
DP  - 2011 Aug
TI  - Blood tests and histological correlates in children with eosinophilic 
      oesophagitis.
PG  - e75-9
LID - 10.1111/j.1651-2227.2011.02210.x [doi]
AB  - AIM: To determine the relationship between blood tests and oesophageal histology 
      in Eosinophilic oesophagitis (EoE). METHODS: All children diagnosed with EoE at 
      one hospital from 2000 to 2009 were considered for inclusion in this study. Three 
      blood test results were analysed, blood eosinophil count, serum total 
      immunoglobulin E (IgE) and radioallergosorbent tests (RAST) to common food 
      allergens. Oesophageal histology was prospectively re-reviewed, and mean 
      eosinophil counts were enumerated. Blood test results were correlated with 
      oesophageal eosinophil counts using Spearman's rank test. RESULTS: Forty children 
      (70% boys) were included in this study, median age at diagnosis 6.5 years (range 
      0-15). At the time of diagnosis, 78% of children had a raised blood eosinophil 
      count, 90% had a raised serum total IgE and 83% had one or more positive RAST 
      tests. The mean oesophageal eosinophil count was significantly correlated with 
      both blood eosinophil count (p=0.008) and serum total IgE level (p=0.008). 
      CONCLUSION: This study shows that blood tests are often abnormal in children with 
      EoE at the time of diagnosis. Our data demonstrate an association between 
      histological abnormalities and blood test results in children with EoE.
CI  - (c) 2011 The Author(s)/Acta Paediatrica (c) 2011 Foundation Acta Paediatrica.
FAU - Marlais, M
AU  - Marlais M
AD  - Department of Paediatric Gastroenterology, Chelsea and Westminster Hospital, and 
      Department of Histopathology, Imperial College Healthcare NHS Trust, London, UK. 
      mm1305@ic.ac.uk
FAU - Francis, N D
AU  - Francis ND
FAU - Fell, J M E
AU  - Fell JM
FAU - Rawat, D J
AU  - Rawat DJ
LA  - eng
PT  - Journal Article
DEP - 20110311
PL  - Norway
TA  - Acta Paediatr
JT  - Acta paediatrica (Oslo, Norway : 1992)
JID - 9205968
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Eosinophilic Esophagitis/blood/*diagnosis/pathology
MH  - Eosinophils
MH  - Esophagus/pathology
MH  - Female
MH  - Food Hypersensitivity/diagnosis
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Infant
MH  - Leukocyte Count
MH  - Male
MH  - Radioallergosorbent Test
EDAT- 2011/03/01 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/03/01 06:00
PHST- 2011/03/01 06:00 [entrez]
PHST- 2011/03/01 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1111/j.1651-2227.2011.02210.x [doi]
PST - ppublish
SO  - Acta Paediatr. 2011 Aug;100(8):e75-9. doi: 10.1111/j.1651-2227.2011.02210.x. Epub 
      2011 Mar 11.