PMID- 21352425
OWN - NLM
STAT- MEDLINE
DCOM- 20110623
LR  - 20111117
IS  - 1399-5448 (Electronic)
IS  - 1399-543X (Linking)
VI  - 12
IP  - 2
DP  - 2011 Mar
TI  - Does the relative risk for type 1 diabetes conferred by HLA-DQ, INS, and PTPN22 
      polymorphisms vary with maternal age, birth weight, or cesarean section?
PG  - 91-4
LID - 10.1111/j.1399-5448.2010.00669.x [doi]
AB  - BACKGROUND AND OBJECTIVE: Maternal age at birth, birth weight, and cesarean 
      section has been associated with a weak but significant increase in risk of type 
      1 diabetes. The objective was to assess whether the relative risk for type 1 
      diabetes conferred by established susceptibility loci human leukocyte antigen 
      (HLA)-DQ, INS, and PTPN22 differed depending on these perinatal factors. METHODS: 
      We employed a case-control study with 456 cases of type 1 diabetes diagnosed 
      before 15 yr of age and 1377 population-based control children. HLA genotypes 
      were divided into high to moderate risk (DQ8/DQ2, DQ8/DQ8, DQ8/X, DQ2/DQ2) vs. 
      all other genotypes. Case-only analysis using logistic regression was used to 
      test for significant interaction. RESULTS: There was no significant difference in 
      the relative risks conferred by HLA-DQ, INS, or PTPN22 by maternal age, birth 
      weight, or mode of delivery, except the relative risk conferred by PTPN22 which 
      was 2.11 [95% confidence interval (CI): 1.64-2.72] for those born vaginally and 
      0.99 (95% CI: 0.50-1.99) for those born by cesarean section [p(interaction) = 
      0.028]. CONCLUSION: The relative risks conferred by the three established 
      susceptibility genes investigated here were independent of the perinatal factors, 
      apart from a possible interaction between PTPN22 and mode of delivery.
CI  - (c) 2010 John Wiley & Sons A/S.
FAU - Stene, Lars C
AU  - Stene LC
AD  - Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway. 
      lars.christian.stene@fhi.no
FAU - Ronningen, Kjersti S
AU  - Ronningen KS
FAU - Undlien, Dag E
AU  - Undlien DE
FAU - Joner, Geir
AU  - Joner G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100906
PL  - Denmark
TA  - Pediatr Diabetes
JT  - Pediatric diabetes
JID - 100939345
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (Insulin)
RN  - EC 3.1.3.48 (PTPN22 protein, human)
RN  - EC 3.1.3.48 (Protein Tyrosine Phosphatase, Non-Receptor Type 22)
SB  - IM
MH  - Birth Weight/genetics/*physiology
MH  - Case-Control Studies
MH  - *Cesarean Section
MH  - Child
MH  - Diabetes Mellitus, Type 1/*etiology/genetics
MH  - Female
MH  - Genetic Predisposition to Disease/etiology
MH  - HLA-DQ Antigens/*genetics
MH  - Humans
MH  - Infant, Newborn
MH  - Insulin/*genetics
MH  - Male
MH  - *Maternal Age
MH  - *Polymorphism, Genetic/physiology
MH  - Pregnancy
MH  - Protein Tyrosine Phosphatase, Non-Receptor Type 22/*genetics
MH  - Risk
EDAT- 2011/03/01 06:00
MHDA- 2011/06/24 06:00
CRDT- 2011/03/01 06:00
PHST- 2011/03/01 06:00 [entrez]
PHST- 2011/03/01 06:00 [pubmed]
PHST- 2011/06/24 06:00 [medline]
AID - 10.1111/j.1399-5448.2010.00669.x [doi]
PST - ppublish
SO  - Pediatr Diabetes. 2011 Mar;12(2):91-4. doi: 10.1111/j.1399-5448.2010.00669.x. 
      Epub 2010 Sep 6.